GALE Antibody - #DF12611
| 製品: | GALE Antibody |
| カタログ: | DF12611 |
| タンパク質の説明: | Rabbit polyclonal antibody to GALE |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 38 kDa; 38kD(Calculated). |
| ユニプロット: | Q14376 |
| RRID: | AB_2845573 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12611, RRID:AB_2845573.
折りたたみ／展開
FLJ95174; FLJ97302; Galactose 4 epimerase UDP; Galactowaldenase; galE; GALE_HUMAN; OTTHUMP00000002991; OTTHUMP00000002994; OTTHUMP00000037931; OTTHUMP00000044857; SDR1E1; short chain dehydrogenase/reductase family 1E member 1; UDP galactose 4 epimerase; UDP galactose 4' epimerase; UDP glucose 4 epimerase; UDP-galactose 4-epimerase; UDP-glucose 4-epimerase;
免疫原
- Q14376 GALE_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q14376 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S44 | Phosphorylation | Uniprot | |
| Y80 | Phosphorylation | Uniprot | |
| S81 | Phosphorylation | Uniprot | |
| S97 | Phosphorylation | Uniprot | |
| K100 | Ubiquitination | Uniprot | |
| Y104 | Phosphorylation | Uniprot | |
| K120 | Ubiquitination | Uniprot | |
| Y157 | Phosphorylation | Uniprot | |
| K159 | Ubiquitination | Uniprot | |
| K161 | Ubiquitination | Uniprot | |
| K176 | Ubiquitination | Uniprot | |
| T232 | Phosphorylation | Uniprot | |
| K249 | Ubiquitination | Uniprot | |
| K259 | Ubiquitination | Uniprot | |
| K286 | Ubiquitination | Uniprot | |
| K295 | Ubiquitination | Uniprot | |
| K338 | Ubiquitination | Uniprot |
研究背景
Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
Homodimer.
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
研究領域
· Metabolism > Carbohydrate metabolism > Galactose metabolism.
· Metabolism > Carbohydrate metabolism > Amino sugar and nucleotide sugar metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
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