GSPT2 Antibody - #DF12622
| 製品: | GSPT2 Antibody |
| カタログ: | DF12622 |
| タンパク質の説明: | Rabbit polyclonal antibody to GSPT2 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 分子量: | 69 kDa; 69kD(Calculated). |
| ユニプロット: | Q8IYD1 |
| RRID: | AB_2845584 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12622, RRID:AB_2845584.
折りたたみ／展開
eRF3b; ERF3B_HUMAN; Eukaryotic peptide chain release factor GTP-binding subunit ERF3B; Eukaryotic peptide chain release factor subunit 3b; G1 to S phase transition 2; G1 to S phase transition protein 2 homolog; Gspt2; GST2; peptide chain release factor 3;
免疫原
- Q8IYD1 ERF3B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDSGSSSSDSAPDCWDQVDMESPGSAPSGDGVSSAVAEAQREPLSSAFSRKLNVNAKPFVPNVHAAEFVPSFLRGPTQPPTLPAGSGSNDETCTGAGYPQGKRMGRGAPVEPSREEPLVSLEGSNSAVTMELSEPVVENGEVEMALEESWEHSKEVSEAEPGGGSSGDSGPPEESGQEMMEEKEEIRKSKSVIVPSGAPKKEHVNVVFIGHVDAGKSTIGGQIMFLTGMVDKRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETERKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINKMDDPTVNWSIERYEECKEKLVPFLKKVGFSPKKDIHFMPCSGLTGANIKEQSDFCPWYTGLPFIPYLDNLPNFNRSIDGPIRLPIVDKYKDMGTVVLGKLESGSIFKGQQLVMMPNKHNVEVLGILSDDTETDFVAPGENLKIRLKGIEEEEILPGFILCDPSNLCHSGRTFDVQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALISLVDKKSGEKSKTRPRFVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVPEKD
PTMs - Q8IYD1 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S71 | Phosphorylation | Uniprot | |
| K102 | Acetylation | Uniprot | |
| S113 | Phosphorylation | Uniprot | |
| S191 | Phosphorylation | Uniprot | |
| S196 | Phosphorylation | Uniprot | |
| K237 | Acetylation | Uniprot | |
| K237 | Ubiquitination | Uniprot | |
| Y238 | Phosphorylation | Uniprot | |
| T249 | Phosphorylation | Uniprot | |
| T258 | Phosphorylation | Uniprot | |
| K267 | Ubiquitination | Uniprot | |
| K281 | Ubiquitination | Uniprot | |
| K316 | Ubiquitination | Uniprot | |
| T321 | Phosphorylation | Uniprot | |
| K325 | Acetylation | Uniprot | |
| K325 | Methylation | Uniprot | |
| K325 | Ubiquitination | Uniprot | |
| K337 | Acetylation | Uniprot | |
| K337 | Ubiquitination | Uniprot | |
| K369 | Ubiquitination | Uniprot | |
| K375 | Acetylation | Uniprot | |
| K376 | Acetylation | Uniprot | |
| S380 | Phosphorylation | Uniprot | |
| K382 | Acetylation | Uniprot | |
| T444 | Phosphorylation | Uniprot | |
| K577 | Ubiquitination | Uniprot | |
| K598 | Acetylation | Uniprot | |
| K598 | Ubiquitination | Uniprot | |
| T607 | Phosphorylation | Uniprot | |
| K613 | Ubiquitination | Uniprot | |
| K619 | Acetylation | Uniprot | |
| K619 | Ubiquitination | Uniprot | |
| K622 | Acetylation | Uniprot | |
| K622 | Ubiquitination | Uniprot |
研究背景
Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.
Cytoplasm.
Highly expressed in IUCC stage II colorectal cancer (CRC).
Interacts with ETF1 (By similarity). Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. Interacts with UPF1 and PABPC1.
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. ERF3 subfamily.
研究領域
· Genetic Information Processing > Translation > mRNA surveillance pathway.
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