製品: NDUFV3 Antibody
カタログ: DF12666
タンパク質の説明: Rabbit polyclonal antibody to NDUFV3
アプリケーション: WB
反応性: Human
予測: Zebrafish
分子量: 10 kDa; 12kD(Calculated).
ユニプロット: P56181
RRID: AB_2845628

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
予測:
Zebrafish(80%)
クローナリティ:
Polyclonal
特異性:
NDUFV3 Antibody detects endogenous levels of total NDUFV3.
RRID:
AB_2845628
引用形式: Affinity Biosciences Cat# DF12666, RRID:AB_2845628.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

CI-10k; CI-9kD; complex I 10kDa subunit; complex I, mitochondrial respiratory chain, 10-kD subunit; Complex I-9kD; mitochondrial NADH oxidoreductase-like protein; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial; NADH ubiquinone oxidoreductase 9 kD subunit; NADH-ubiquinone oxidoreductase 9 kDa subunit; NADH-ubiquinone oxidoreductase flavoprotein 3, 10kD; NDUFV3; NDUV3_HUMAN; Renal carcinoma antigen NY-REN-4;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
タンパク質配列:
MAAPCLLRQGRAGALKTMLQEAQVFRGLASTVSLSAESGKSEKGQPQNSKKQSPPKKPAPVPAEPFDNTTYKNLQHHDYSTYTFLDLNLELSKFRMPQPSSGRESPRH

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Zebrafish
80
Horse
71
Dog
55
Bovine
33
Pig
0
Sheep
0
Xenopus
0
Chicken
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P56181 基板として

Site PTM Type Enzyme
S100 Phosphorylation
S101 Phosphorylation
S105 Phosphorylation

研究背景

機能:

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.

細胞の位置付け:

Mitochondrion inner membrane>Peripheral membrane protein>Matrix side.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
サブユニット構造:

Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.

タンパク質ファミリー:

Belongs to the complex I NDUFV3 subunit family.

研究領域

· Human Diseases > Endocrine and metabolic diseases > Non-alcoholic fatty liver disease (NAFLD).

· Human Diseases > Neurodegenerative diseases > Alzheimer's disease.

· Human Diseases > Neurodegenerative diseases > Parkinson's disease.

· Human Diseases > Neurodegenerative diseases > Huntington's disease.

· Metabolism > Energy metabolism > Oxidative phosphorylation.

· Metabolism > Global and overview maps > Metabolic pathways.

· Organismal Systems > Nervous system > Retrograde endocannabinoid signaling.   (View pathway)

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