OAS2 Antibody - #DF12680
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| 製品: | OAS2 Antibody |
| カタログ: | DF12680 |
| タンパク質の説明: | Rabbit polyclonal antibody to OAS2 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse |
| 予測: | Bovine, Horse, Rabbit, Dog |
| 分子量: | 66 kDa, 70 kDa; 82kD(Calculated). |
| ユニプロット: | P29728 |
| RRID: | AB_2845642 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12680, RRID:AB_2845642.
折りたたみ／展開
(2-5'')oligo(A) synthase 2; (2-5')oligo(A) synthetase 2; 2''-5''-oligoadenylate synthase 2; 2'-5'-oligoadenylate synthetase 2; 2'-5'-oligoadenylate synthetase 2, 69/71kDa; 2-5A synthase 2; 2-5A synthetase 2; 2-prime, 5-prime-oligoadenylate synthetase 2 edit item name - 2-prime, 5-prime-oligoadenylate synthetase 2, 69-KD; 2-prime, 5-prime-oligoadenylate synthetase 2; MGC78578; OAS2; OAS2_HUMAN; p69; p69 OAS / p71 OAS; p69OAS / p71OAS;
免疫原
- P29728 OAS2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGNGESQLSSVPAQKLGWFIQEYLKPYEECQTLIDEMVNTICDVLQEPEQFPLVQGVAIGGSYGRKTVLRGNSDGTLVLFFSDLKQFQDQKRSQRDILDKTGDKLKFCLFTKWLKNNFEIQKSLDGFTIQVFTKNQRISFEVLAAFNALSLNDNPSPWIYRELKRSLDKTNASPGEFAVCFTELQQKFFDNRPGKLKDLILLIKHWHQQCQKKIKDLPSLSPYALELLTVYAWEQGCRKDNFDIAEGVRTVLELIKCQEKLCIYWMVNYNFEDETIRNILLHQLQSARPVILDPVDPTNNVSGDKICWQWLKKEAQTWLTSPNLDNELPAPSWNVLPAPLFTTPGHLLDKFIKEFLQPNKCFLEQIDSAVNIIRTFLKENCFRQSTAKIQIVRGGSTAKGTALKTGSDADLVVFHNSLKSYTSQKNERHKIVKEIHEQLKAFWREKEEELEVSFEPPKWKAPRVLSFSLKSKVLNESVSFDVLPAFNALGQLSSGSTPSPEVYAGLIDLYKSSDLPGGEFSTCFTVLQRNFIRSRPTKLKDLIRLVKHWYKECERKLKPKGSLPPKYALELLTIYAWEQGSGVPDFDTAEGFRTVLELVTQYQQLCIFWKVNYNFEDETVRKFLLSQLQKTRPVILDPAEPTGDVGGGDRWCWHLLAKEAKEWLSSPCFKDGTGNPIPPWKVPTMQTPGSCGARIHPIVNEMFSSRSHRILNNNSKRNF
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P29728 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| G2 | Myristoylation | Uniprot | |
| K134 | Ubiquitination | Uniprot | |
| K169 | Ubiquitination | Uniprot | |
| K187 | Ubiquitination | Uniprot | |
| K195 | Ubiquitination | Uniprot | |
| K212 | Ubiquitination | Uniprot | |
| T250 | Phosphorylation | Uniprot | |
| K360 | Acetylation | Uniprot | |
| K360 | Ubiquitination | Uniprot | |
| S368 | Phosphorylation | Uniprot | |
| K378 | Acetylation | Uniprot | |
| K378 | Ubiquitination | Uniprot | |
| S385 | Phosphorylation | Uniprot | |
| K388 | Ubiquitination | Uniprot | |
| K399 | Ubiquitination | Uniprot | |
| K404 | Ubiquitination | Uniprot | |
| S407 | Phosphorylation | Uniprot | |
| S417 | Phosphorylation | Uniprot | |
| K419 | Ubiquitination | Uniprot | |
| S423 | Phosphorylation | Uniprot | |
| K425 | Ubiquitination | Uniprot | |
| K433 | Acetylation | Uniprot | |
| K433 | Ubiquitination | Uniprot | |
| K440 | Ubiquitination | Uniprot | |
| S466 | Phosphorylation | Uniprot | |
| S468 | Phosphorylation | Uniprot | |
| K472 | Ubiquitination | Uniprot | |
| K622 | Ubiquitination | Uniprot | |
| K661 | Ubiquitination | Uniprot |
研究背景
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation. Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates (By similarity). Non-infected lobules would not be affected, allowing efficient pup feeding during infection (By similarity).
Myristoylation is not essential for its activity.
Glycosylated. Glycosylation is essential for its activity.
Cytoplasm. Cytoplasm>Perinuclear region.
Homodimer.
Belongs to the 2-5A synthase family.
研究領域
· Human Diseases > Infectious diseases: Viral > Hepatitis C.
· Human Diseases > Infectious diseases: Viral > Measles.
· Human Diseases > Infectious diseases: Viral > Influenza A.
· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.
· Organismal Systems > Immune system > NOD-like receptor signaling pathway. (View pathway)
参考文献
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