OSMR Antibody - #DF12682
| 製品: | OSMR Antibody |
| カタログ: | DF12682 |
| タンパク質の説明: | Rabbit polyclonal antibody to OSMR |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Monkey |
| 予測: | Pig, Sheep, Rabbit, Dog, Xenopus |
| 分子量: | 111 kDa; 111kD(Calculated). |
| ユニプロット: | Q99650 |
| RRID: | AB_2845644 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12682, RRID:AB_2845644.
折りたたみ／展開
IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB; Interleukin-31 receptor subunit beta; MGC140467; MGC150626; MGC150627; MGC75127; Oncostatin M receptor; Oncostatin M specific receptor subunit beta; Oncostatin M-specific receptor, beta; Oncostatin-M-specific receptor subunit beta; Osmr; OSMR_HUMAN; OSMRB;
免疫原
Expressed in keratinocytes (at protein level) (PubMed:21261663). Expressed at relatively high levels in all neural cells as well as fibroblast and epithelial cells (PubMed:8999038).
- Q99650 OSMR_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MALFAVFQTTFFLTLLSLRTYQSEVLAERLPLTPVSLKVSTNSTRQSLHLQWTVHNLPYHQELKMVFQIQISRIETSNVIWVGNYSTTVKWNQVLHWSWESELPLECATHFVRIKSLVDDAKFPEPNFWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEEGTNVTICYVSRNIQNNVSCYLEGKQIHGEQLDPHVTAFNLNSVPFIRNKGTNIYCEASQGNVSEGMKGIVLFVSKVLEEPKDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTLFESFSGEKKLCTHKNWCNWQITQDSQETYNFTLIAENYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSIRNNFTYLCQIELHGEGKMMQYNVSIKVNGEYFLSELEPATEYMARVRCADASHFWKWSEWSGQNFTTLEAAPSEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPSSSELHSIPAPANSTKLILDRCSYQICVIANNSVGASPASVIVISADPENKEVEEERIAGTEGGFSLSWKPQPGDVIGYVVDWCDHTQDVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDFRIYGLSTKRIACLLEKKTGYSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQGYHVYLKSKARQCHPRFEKAVLSDGSECCKYKIDNPEEKALIVDNLKPESFYEFFITPFTSAGEGPSATFTKVTTPDEHSSMLIHILLPMVFCVLLIMVMCYLKSQWIKETCYPDIPDPYKSSILSLIKFKENPHLIIMNVSDCIPDAIEVVSKPEGTKIQFLGTRKSLTETELTKPNYLYLLPTEKNHSGPGPCICFENLTYNQAASDSGSCGHVPVSPKAPSMLGLMTSPENVLKALEKNYMNSLGEIPAGETSLNYVSQLASPMFGDKDSLPTNPVEAPHCSEYKMQMAVSLRLALPPPTENSSLSSITLLDPGEHYC
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q99650 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T33 | Phosphorylation | Uniprot | |
| K115 | Ubiquitination | Uniprot | |
| Y168 | Phosphorylation | Uniprot | |
| Y180 | Phosphorylation | Uniprot | |
| K209 | Ubiquitination | Uniprot | |
| K241 | Ubiquitination | Uniprot | |
| K251 | Ubiquitination | Uniprot | |
| K269 | Ubiquitination | Uniprot | |
| K285 | Ubiquitination | Uniprot | |
| S382 | Phosphorylation | Uniprot | |
| Y389 | Phosphorylation | Uniprot | |
| K615 | Ubiquitination | Uniprot | |
| K677 | Ubiquitination | Uniprot | |
| K688 | Ubiquitination | Uniprot | |
| Y689 | Phosphorylation | Uniprot | |
| K767 | Ubiquitination | Uniprot | |
| K779 | Ubiquitination | Uniprot | |
| S784 | Phosphorylation | Uniprot | |
| K787 | Ubiquitination | Uniprot | |
| K789 | Ubiquitination | Uniprot | |
| S800 | Phosphorylation | Uniprot | |
| K812 | Ubiquitination | Uniprot | |
| K817 | Ubiquitination | Uniprot | |
| K825 | Ubiquitination | Uniprot | |
| S826 | Phosphorylation | Uniprot | |
| T828 | Phosphorylation | Uniprot | |
| T830 | Phosphorylation | Uniprot | |
| K834 | Ubiquitination | Uniprot | |
| Y837 | Phosphorylation | Uniprot | |
| Y839 | Phosphorylation | Uniprot | |
| K845 | Ubiquitination | Uniprot | |
| T860 | Phosphorylation | Uniprot | |
| Y861 | Phosphorylation | Uniprot | |
| S877 | Phosphorylation | Uniprot | |
| K879 | Ubiquitination | Uniprot | |
| S889 | Phosphorylation | Uniprot | |
| K895 | Ubiquitination | Uniprot | |
| K899 | Ubiquitination | Uniprot | |
| Y901 | Phosphorylation | Uniprot | |
| Y917 | Phosphorylation | Uniprot | |
| K929 | Ubiquitination | Uniprot | |
| Y945 | Phosphorylation | Uniprot | |
| Y978 | Phosphorylation | Uniprot |
研究背景
Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.
Membrane>Single-pass type I membrane protein.
Expressed in keratinocytes (at protein level). Expressed at relatively high levels in all neural cells as well as fibroblast and epithelial cells.
Heterodimer composed of OSMR and IL6ST (type II OSM receptor). Heterodimer with IL31RA to form the IL31 receptor.
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.
Belongs to the type I cytokine receptor family. Type 2 subfamily.
研究領域
· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction. (View pathway)
· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway. (View pathway)
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