製品: PIP5K1B Antibody
カタログ: DF12698
タンパク質の説明: Rabbit polyclonal antibody to PIP5K1B
アプリケーション: WB
反応性: Human, Mouse, Rat
予測: Pig, Horse, Sheep, Rabbit, Dog, Xenopus
分子量: 62 kDa; 61kD(Calculated).
ユニプロット: O14986
RRID: AB_2845659

類似製品を見る>>

   サイズ 価格 在庫状況
 100ul $280 在庫あり
 200ul $350 在庫あり

リードタイム: 当日配達

For pricing and ordering contact:
お問い合わせ先

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Xenopus(100%)
クローナリティ:
Polyclonal
特異性:
PIP5K1B Antibody detects endogenous levels of total PIP5K1B.
RRID:
AB_2845659
引用形式: Affinity Biosciences Cat# DF12698, RRID:AB_2845659.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

MSS 4; MSS4; Phosphatidylinositol 4 phosphate 5 kinase type 1 beta; Phosphatidylinositol-4-phosphate 5-kinase type I beta; Phosphatidylinositol-4-phosphate 5-kinase type-1 beta; PI4P5K 1 beta; PI51B_HUMAN; PIP5K1-beta; PIP5K1B; PIP5KIbeta; Pipk 5 beta; Pipk 5b; Protein STM 7; Protein STM-7; PtdIns(4)P-5-kinase 1 beta; STM 7; STM7; STM7 LSB; Type I phosphatidylinositol 4 phosphate 5 kinase beta; Type I phosphatidylinositol-4-phosphate 5-kinase beta;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
発現特異性:
O14986 PI51B_HUMAN:

Detected in heart, pancreas, brain, kidney, skeletal muscle and lung.

タンパク質配列:
MSSAAENGEAAPGKQNEEKTYKKTASSAIKGAIQLGIGYTVGNLTSKPERDVLMQDFYVVESVFLPSEGSNLTPAHHYPDFRFKTYAPLAFRYFRELFGIKPDDYLYSICSEPLIELSNPGASGSLFFVTSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCMQSGGINIRIVVMNNVLPRSMRMHFTYDLKGSTYKRRASRKEREKSNPTFKDLDFLQDMHEGLYFDTETYNALMKTLQRDCRVLESFKIMDYSLLLGIHFLDHSLKEKEEETPQNVPDAKRTGMQKVLYSTAMESIQGPGKSGDGIITENPDTMGGIPAKSHRGEKLLLFMGIIDILQSYRLMKKLEHSWKALVYDGDTVSVHRPSFYADRFLKFMNSRVFKKIQALKASPSKKRCNSIAALKATSQEIVSSISQEWKDEKRDLLTEGQSFSSLDEEALGSRHRPDLVPSTPSLFEAASLATTISSSSLYVNEHYPHDRPTLYSNSKGLPSSSTFTLEEGTIYLTAEPNTLEVQDDNASVLDVYL

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Sheep
100
Dog
100
Xenopus
100
Rabbit
100
Bovine
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - O14986 基板として

Site PTM Type Enzyme
S2 Phosphorylation
S3 Phosphorylation
K47 Ubiquitination
Y105 Phosphorylation P43405 (SYK)
K143 Ubiquitination
K150 Ubiquitination
T165 Phosphorylation
K205 Ubiquitination
K301 Methylation
K360 Ubiquitination
S405 Phosphorylation
S413 Phosphorylation P17252 (PRKCA)
S421 Phosphorylation
S445 Phosphorylation
S448 Phosphorylation

研究背景

機能:

Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion (By similarity).

細胞の位置付け:

Endomembrane system.
Note: Associated with membranes.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Detected in heart, pancreas, brain, kidney, skeletal muscle and lung.

サブユニット構造:

Interacts with RAC1, AJUBA, PLD1, PLD2 and ARF1.

研究領域

· Cellular Processes > Transport and catabolism > Endocytosis.   (View pathway)

· Cellular Processes > Cell motility > Regulation of actin cytoskeleton.   (View pathway)

· Environmental Information Processing > Signal transduction > Phosphatidylinositol signaling system.

· Environmental Information Processing > Signal transduction > Phospholipase D signaling pathway.   (View pathway)

· Human Diseases > Cancers: Overview > Choline metabolism in cancer.   (View pathway)

· Metabolism > Carbohydrate metabolism > Inositol phosphate metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

· Organismal Systems > Immune system > Fc gamma R-mediated phagocytosis.   (View pathway)

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.