PTGES2 Antibody - #DF12712
| 製品: | PTGES2 Antibody |
| カタログ: | DF12712 |
| タンパク質の説明: | Rabbit polyclonal antibody to PTGES2 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Dog |
| 分子量: | 30 kDa; 42kD(Calculated). |
| ユニプロット: | Q9H7Z7 |
| RRID: | AB_2845673 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12712, RRID:AB_2845673.
折りたたみ／展開
C9orf15; FLJ14038; Gamma interferon activated transcriptional element binding factor 1; GATE binding factor 1; GBF 1; GBF1; Membrane associated prostaglandin E synthase 2; MGC11289; Microsomal prostaglandin E synthase 2; mPGES 2; mPGES-2; PGES2; PGES2_HUMAN; Prostaglandin E synthase 2; Prostaglandin E synthase 2 truncated form; PTGES 2; PTGES2;
免疫原
Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain: cerebellum; occipital, frontal and parietal lobes. Also expressed in the lymph nodes, skeletal muscle, kidney and trachea, but not in the thymus or lung. Overexpressed in colorectal cancer.
- Q9H7Z7 PGES2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDPAARVVRALWPGGCALAWRLGGRPQPLLPTQSRAGFAGAAGGPSPVAAARKGSPRLLGAAALALGGALGLYHTARWHLRAQDLHAERSAAQLSLSSRLQLTLYQYKTCPFCSKVRAFLDFHALPYQVVEVNPVRRAEIKFSSYRKVPILVAQEGESSQQLNDSSVIISALKTYLVSGQPLEEIITYYPAMKAVNEQGKEVTEFGNKYWLMLNEKEAQQVYGGKEARTEEMKWRQWADDWLVHLISPNVYRTPTEALASFDYIVREGKFGAVEGAVAKYMGAAAMYLISKRLKSRHRLQDNVREDLYEAADKWVAAVGKDRPFMGGQKPNLADLAVYGVLRVMEGLDAFDDLMQHTHIQPWYLRVERAITEASPAH
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9H7Z7 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S46 | Phosphorylation | Uniprot | |
| K53 | Acetylation | Uniprot | |
| T75 | Phosphorylation | Uniprot | |
| S90 | Phosphorylation | Uniprot | |
| S95 | Phosphorylation | Uniprot | |
| S97 | Phosphorylation | Uniprot | |
| T109 | Phosphorylation | Uniprot | |
| K115 | Ubiquitination | Uniprot | |
| Y127 | Phosphorylation | Uniprot | |
| K141 | Ubiquitination | Uniprot | |
| K147 | Ubiquitination | Uniprot | |
| Y188 | Phosphorylation | Uniprot | |
| K193 | Ubiquitination | Uniprot | |
| K200 | Ubiquitination | Uniprot | |
| T203 | Phosphorylation | Uniprot | |
| K208 | Ubiquitination | Uniprot | |
| Y209 | Phosphorylation | Uniprot | |
| K216 | Ubiquitination | Uniprot | |
| K225 | Ubiquitination | Uniprot | |
| K233 | Ubiquitination | Uniprot | |
| S260 | Phosphorylation | Uniprot | |
| Y263 | Phosphorylation | Uniprot | |
| K269 | Ubiquitination | Uniprot | |
| Y280 | Phosphorylation | Uniprot | |
| Y287 | Phosphorylation | Uniprot | |
| S290 | Phosphorylation | Uniprot | |
| Y308 | Phosphorylation | Uniprot | |
| K313 | Ubiquitination | Uniprot | |
| T371 | Phosphorylation | Uniprot | |
| S374 | Phosphorylation | Uniprot |
研究背景
Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2).
Golgi apparatus membrane>Single-pass membrane protein.
Cytoplasm>Perinuclear region.
Note: Synthesized as a Golgi membrane-bound protein, which is further cleaved into the predominant soluble truncated form. The truncated form is cytoplasmic and is enriched in the perinuclear region.
Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain: cerebellum; occipital, frontal and parietal lobes. Also expressed in the lymph nodes, skeletal muscle, kidney and trachea, but not in the thymus or lung. Overexpressed in colorectal cancer.
Homodimer. May interact with CEBPB (By similarity). Interacts with EXOSC10.
Belongs to the GST superfamily.
研究領域
· Metabolism > Lipid metabolism > Arachidonic acid metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
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