RMI1 Antibody - #DF12724
| 製品: | RMI1 Antibody |
| カタログ: | DF12724 |
| タンパク質の説明: | Rabbit polyclonal antibody to RMI1 |
| アプリケーション: | WB |
| 反応性: | Human |
| 分子量: | 75 kDa; 70kD(Calculated). |
| ユニプロット: | Q9H9A7 |
| RRID: | AB_2845685 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12724, RRID:AB_2845685.
折りたたみ／展開
BLAP75; BLM associated polypeptide 75 kDa; BLM associated protein 75 kDa; BLM-associated protein of 75 kDa; C9orf76; FAAP75; FLJ12888; Homolog of yeast RecQ mediated genome instability 1; RecQ mediated genome instability 1; RecQ-mediated genome instability protein 1; Rmi1; RMI1 homolog; RMI1 RecQ mediated genome instability 1 homolog; RMI1_HUMAN; RP11-346I8;
免疫原
- Q9H9A7 RMI1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNVTSIALRAETWLLAAWHVKVPPMWLEACINWIQEENNNVNLSQAQMNKQVFEQWLLTDLRDLEHPLLPDGILEIPKGELNGFYALQINSLVDVSQPAYSQIQKLRGKNTTNDLVTAEAQVTPKPWEAKPSRMLMLQLTDGIVQIQGMEYQPIPILHSDLPPGTKILIYGNISFRLGVLLLKPENVKVLGGEVDALLEEYAQEKVLARLIGEPDLVVSVIPNNSNENIPRVTDVLDPALGPSDEELLASLDENDELTANNDTSSERCFTTGSSSNTIPTRQSSFEPEFVISPRPKEEPSNLSIHVMDGELDDFSLEEALLLEETVQKEQMETKELQPLTFNRNADRSIERFSHNPNTTNNFSLTCKNGNNNWSEKNVSEQMTNEDKSFGCPSVRDQNRSIFSVHCNVPLAHDFTNKEKNLETDNKIKQTSSSDSHSLNNKILNREVVNYVQKRNSQISNENDCNLQSCSLRSSENSINLSIAMDLYSPPFVYLSVLMASKPKEVTTVKVKAFIVTLTGNLSSSGGIWSITAKVSDGTAYLDVDFVDEILTSLIGFSVPEMKQSKKDPLQYQKFLEGLQKCQRDLIDLCCLMTISFNPSLSKAMVLALQDVNMEHLENLKKRLNK
PTMs - Q9H9A7 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| T4 | Phosphorylation | Uniprot | |
| K109 | Ubiquitination | Uniprot | |
| T111 | Phosphorylation | Uniprot | |
| T112 | Phosphorylation | Uniprot | |
| T123 | Phosphorylation | Uniprot | |
| K125 | Ubiquitination | Uniprot | |
| K130 | Ubiquitination | Uniprot | |
| S132 | Phosphorylation | Uniprot | |
| K205 | Ubiquitination | Uniprot | |
| S219 | Phosphorylation | Uniprot | |
| S225 | Phosphorylation | Uniprot | |
| S250 | Phosphorylation | Uniprot | |
| T277 | Phosphorylation | Uniprot | |
| T280 | Phosphorylation | Uniprot | |
| S283 | Phosphorylation | Uniprot | |
| S284 | Phosphorylation | Uniprot | |
| S292 | Phosphorylation | Uniprot | |
| K334 | Sumoylation | Uniprot | |
| K334 | Ubiquitination | Uniprot | |
| T359 | Phosphorylation | Uniprot | |
| S363 | Phosphorylation | Uniprot | |
| K376 | Ubiquitination | Uniprot | |
| T383 | Phosphorylation | Uniprot | |
| K387 | Ubiquitination | Uniprot | |
| S388 | Phosphorylation | Uniprot | |
| S400 | Phosphorylation | Uniprot | |
| S403 | Phosphorylation | Uniprot | |
| T415 | Phosphorylation | Uniprot | |
| K428 | Ubiquitination | Uniprot | |
| K441 | Ubiquitination | Uniprot | |
| Y450 | Phosphorylation | Uniprot | |
| K453 | Ubiquitination | Uniprot | |
| S456 | Phosphorylation | Uniprot | |
| S524 | Phosphorylation | Uniprot | |
| K566 | Ubiquitination | Uniprot | |
| K573 | Ubiquitination | Uniprot | |
| K580 | Ubiquitination | Uniprot |
研究背景
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
Nucleus.
Note: Forms foci in response to DNA damage.
Component of the RMI complex, containing at least TOP3A, RMI1 and RMI2. The RMI complex interacts with BLM. Directly interacts with RMI2 and TOP3A. May bind DHJ. Interacts (via N-terminal region) with BLM; the interaction is direct.
Belongs to the RMI1 family.
研究領域
· Genetic Information Processing > Replication and repair > Fanconi anemia pathway.
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