RNASEH2C Antibody - #DF12725
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12725, RRID:AB_2845686.
折りたたみ／展開
AGS3; Aicardi-Goutieres syndrome 3 protein; AYP1; Ribonuclease H2 subunit C; Ribonuclease HI subunit C; RNase H1 small subunit; RNASEH2C; RNH2C;
免疫原
- Q8TDP1 RNH2C_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MESGDEAAIERHRVHLRSATLRDAVPATLHLLPCEVAVDGPAPVGRFFTPAIRQGPEGLEVSFRGRCLRGEEVAVPPGLVGYVMVTEEKKVSMGKPDPLRDSGTDDQEEEPLERDFDRFIGATANFSRFTLWGLETIPGPDAKVRGALTWPSLAAAIHAQVPED
PTMs - Q8TDP1 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| S3 | Phosphorylation | Uniprot | |
| S62 | Phosphorylation | Uniprot | |
| R64 | Methylation | Uniprot | |
| S92 | Phosphorylation | Uniprot | |
| S102 | Phosphorylation | Uniprot | |
| R114 | Methylation | Uniprot | |
| K143 | Sumoylation | Uniprot | |
| K143 | Ubiquitination | Uniprot |
研究背景
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
Nucleus.
Widely expressed.
The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.
Belongs to the RNase H2 subunit C family.
研究領域
· Genetic Information Processing > Replication and repair > DNA replication.
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