SESN3 Antibody - #DF12735
| 製品: | SESN3 Antibody |
| カタログ: | DF12735 |
| タンパク質の説明: | Rabbit polyclonal antibody to SESN3 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat, Monkey |
| 予測: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 57 kDa; 57kD(Calculated). |
| ユニプロット: | P58005 |
| RRID: | AB_2845696 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12735, RRID:AB_2845696.
折りたたみ／展開
MGC29667; OTTHUMP00000236979; OTTHUMP00000236986; SESN3; SESN3_HUMAN; SEST3; Sestrin 3; Sestrin-3;
免疫原
- P58005 SESN3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNRGGGSPSAAANYLLCTNCRKVLRKDKRIRVSQPLTRGPSAFIPEKEVVQANTVDERTNFLVEEYSTSGRLDNITQVMSLHTQYLESFLRSQFYMLRMDGPLPLPYRHYIAIMAAARHQCSYLINMHVDEFLKTGGIAEWLNGLEYVPQRLKNLNEINKLLAHRPWLITKEHIQKLVKTGENNWSLPELVHAVVLLAHYHALASFVFGSGINPERDPEISNGFRLISVNNFCVCDLANDNNIENASLSGSNFGIVDSLSELEALMERMKRLQEEREDEEASQEEMSTRFEKEKKESLFVVSGDTFHSFPHSDFEDDMIITSDVSRYIEDPGFGYEDFARRGEEHLPTFRAQDYTWENHGFSLVNRLYSDIGHLLDEKFRMVYNLTYNTMATHEDVDTTMLRRALFNYVHCMFGIRYDDYDYGEVNQLLERSLKVYIKTVTCYPERTTKRMYDSYWRQFKHSEKVHVNLLLMEARMQAELLYALRAITRHLT
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P58005 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R3 | Methylation | Uniprot | |
| S7 | Phosphorylation | Uniprot | |
| K47 | Ubiquitination | Uniprot | |
| R98 | Methylation | Uniprot | |
| K153 | Ubiquitination | Uniprot | |
| K171 | Ubiquitination | Uniprot | |
| K176 | Ubiquitination | Uniprot | |
| S282 | Phosphorylation | Uniprot | |
| S287 | Phosphorylation | Uniprot | |
| T288 | Phosphorylation | Uniprot | |
| K378 | Ubiquitination | Uniprot | |
| K438 | Ubiquitination | Uniprot | |
| T447 | Phosphorylation | Uniprot | |
| S454 | Phosphorylation | Uniprot | |
| Y455 | Phosphorylation | Uniprot |
研究背景
May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway. May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity). This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity).
Cytoplasm.
Widely expressed.
Interacts with the GATOR2 complex which is composed of MIOS, SEC13, SEH1L, WDR24 and WDR59; the interaction is not regulated by leucine. Interacts with RRAGA, RRAGB, RRAGC and RRAGD; may function as a guanine nucleotide dissociation inhibitor for RRAGs and regulate them. Interacts with the TORC2 complex; through RICTOR (By similarity).
The C-terminal domain may mediate interaction with GATOR2 and regulation of TORC1 signaling.
Belongs to the sestrin family.
研究領域
· Cellular Processes > Cell growth and death > p53 signaling pathway. (View pathway)
· Organismal Systems > Aging > Longevity regulating pathway. (View pathway)
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