STIM2 Antibody - #DF12755
| 製品: | STIM2 Antibody |
| カタログ: | DF12755 |
| タンパク質の説明: | Rabbit polyclonal antibody to STIM2 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 110 kDa; 84kD(Calculated). |
| ユニプロット: | Q9P246 |
| RRID: | AB_2845716 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12755, RRID:AB_2845716.
折りたたみ／展開
FLJ39527; KIAA1482; STIM 2; STIM2; STIM2_HUMAN; Stromal interaction molecule 2;
免疫原
- Q9P246 STIM2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLVLGLLVAGAADGCELVPRHLRGRRATGSAATAASSPAAAAGDSPALMTDPCMSLSPPCFTEEDRFSLEALQTIHKQMDDDKDGGIEVEESDEFIREDMKYKDATNKHSHLHREDKHITIEDLWKRWKTSEVHNWTLEDTLQWLIEFVELPQYEKNFRDNNVKGTTLPRIAVHEPSFMISQLKISDRSHRQKLQLKALDVVLFGPLTRPPHNWMKDFILTVSIVIGVGGCWFAYTQNKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKILEAKKALSELTTCLRERLFRWQQIEKICGFQIAHNSGLPSLTSSLYSDHSWVVMPRVSIPPYPIAGGVDDLDEDTPPIVSQFPGTMAKPPGSLARSSSLCRSRRSIVPSSPQPQRAQLAPHAPHPSHPRHPHHPQHTPHSLPSPDPDILSVSSCPALYRNEEEEEAIYFSAEKQWEVPDTASECDSLNSSIGRKQSPPLSLEIYQTLSPRKISRDEVSLEDSSRGDSPVTVDVSWGSPDCVGLTETKSMIFSPASKVYNGILEKSCSMNQLSSGIPVPKPRHTSCSSAGNDSKPVQEAPSVARISSIPHDLCHNGEKSKKPSKIKSLFKKKSK
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9P246 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K164 | Ubiquitination | Uniprot | |
| S261 | Phosphorylation | Uniprot | |
| K283 | Ubiquitination | Uniprot | |
| K289 | Ubiquitination | Uniprot | |
| Y320 | Phosphorylation | Uniprot | |
| S346 | Phosphorylation | Uniprot | |
| S463 | Phosphorylation | Uniprot | |
| S518 | Phosphorylation | Uniprot | |
| S522 | Phosphorylation | Uniprot | |
| S523 | Phosphorylation | Uniprot | |
| S539 | Phosphorylation | Uniprot | |
| S566 | Phosphorylation | Uniprot | |
| Y581 | Phosphorylation | Uniprot | |
| S583 | Phosphorylation | Uniprot | |
| S599 | Phosphorylation | Uniprot | |
| S603 | Phosphorylation | Uniprot | |
| S609 | Phosphorylation | Uniprot | |
| S613 | Phosphorylation | Uniprot | |
| Y617 | Phosphorylation | Uniprot | |
| T619 | Phosphorylation | Uniprot | |
| S621 | Phosphorylation | Uniprot | |
| S626 | Phosphorylation | Uniprot | |
| S631 | Phosphorylation | Uniprot | |
| S640 | Phosphorylation | Uniprot | |
| S661 | Phosphorylation | Uniprot | |
| S665 | Phosphorylation | Uniprot | |
| S668 | Phosphorylation | Uniprot | |
| S678 | Phosphorylation | Uniprot | |
| S680 | Phosphorylation | Uniprot | |
| S697 | Phosphorylation | Uniprot | |
| C698 | S-Nitrosylation | Uniprot | |
| S699 | Phosphorylation | Uniprot | |
| S700 | Phosphorylation | Uniprot | |
| S713 | Phosphorylation | Uniprot | |
| S718 | Phosphorylation | Uniprot | |
| S719 | Phosphorylation | Uniprot | |
| K742 | Methylation | Uniprot |
研究背景
Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx.
Glycosylated.
Phosphorylated predominantly on Ser residues.
Endoplasmic reticulum membrane>Single-pass type I membrane protein.
Note: Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration.
Expressed in all tissues and tumor cell lines examined.
Oligomer with STIM1. Interacts with ORAI1.
研究領域
· Environmental Information Processing > Signal transduction > Calcium signaling pathway. (View pathway)
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