AMD1 Antibody - #DF12822
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| 製品: | AMD1 Antibody |
| カタログ: | DF12822 |
| タンパク質の説明: | Rabbit polyclonal antibody to AMD1 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Sheep, Rabbit, Dog |
| 分子量: | 38 kDa; 38kD(Calculated). |
| ユニプロット: | P17707 |
| RRID: | AB_2845783 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12822, RRID:AB_2845783.
折りたたみ／展開
Adenosylmethionine decarboxylase 1; AdoMetDC; AMD1; DCAM_HUMAN; EC 4.1.1.50; FLJ26964; S adenosylmethionine decarboxylase 1; S adenosylmethionine decarboxylase proenzyme; S-adenosylmethionine decarboxylase beta chain; SAMDC;
免疫原
- P17707 DCAM_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLASPQKIEGFKRLDCQSAMFNDYNFVFTSFAKKQQQQQS
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P17707 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y63 | Phosphorylation | Uniprot | |
| S73 | Phosphorylation | Uniprot | |
| K96 | Ubiquitination | Uniprot | |
| Y112 | Phosphorylation | Uniprot | |
| S113 | Phosphorylation | Uniprot | |
| K201 | Ubiquitination | Uniprot | |
| K276 | Ubiquitination | Uniprot | |
| K291 | Ubiquitination | Uniprot | |
| S298 | Phosphorylation | Uniprot | |
| K301 | Ubiquitination | Uniprot |
研究背景
Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.
Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.
Heterotetramer of two alpha and two beta chains.
Belongs to the eukaryotic AdoMetDC family.
研究領域
· Metabolism > Amino acid metabolism > Cysteine and methionine metabolism.
· Metabolism > Amino acid metabolism > Arginine and proline metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
参考文献
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