AP3D1 Antibody - #DF12825
| 製品: | AP3D1 Antibody |
| カタログ: | DF12825 |
| タンパク質の説明: | Rabbit polyclonal antibody to AP3D1 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Dog, Chicken, Xenopus |
| 分子量: | 110 kDa; 130kD(Calculated). |
| ユニプロット: | O14617 |
| RRID: | AB_2845786 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12825, RRID:AB_2845786.
折りたたみ／展開
Adapter-related protein complex 3 subunit delta-1; adaptor-related protein complex 3, delta 1 subunit; ADTD; AP 3 complex delta subunit; AP-3 complex subunit delta; AP-3 complex subunit delta-1; ap3d1; AP3D1_HUMAN; Delta 1 subunit of adaptor-related protein complex 3; Delta Adaptin; Delta-adaptin; hBLVR; Subunit of putative vesicle coat adaptor complex AP 3;
免疫原
Present in all adult tissues examined with the highest levels in skeletal muscle, heart, pancreas and testis.
- O14617 AP3D1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MALKMVKGSIDRMFDKNLQDLVRGIRNHKEDEAKYISQCIDEIKQELKQDNIAVKANAVCKLTYLQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLKEKLEDPDPGVQSAAVNVICELARRNPKNYLSLAPLFFKLMTSSTNNWVLIKIIKLFGALTPLEPRLGKKLIEPLTNLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILKTHPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLIAAQMLDVAIRVKAIRKFAVSQMSALLDSAHLLASSTQRNGICEVLYAAAWICGEFSEHLQEPHHTLEAMLRPRVTTLPGHIQAVYVQNVVKLYASILQQKEQAGEAEGAQAVTQLMVDRLPQFVQSADLEVQERASCILQLVKHIQKLQAKDVPVAEEVSALFAGELNPVAPKAQKKVPVPEGLDLDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPESSYSLLAENSYVKMTCDIRGSLQEDSQVTVAIVLENRSSSILKGMELSVLDSLNARMARPQGSSVHDGVPVPFQLPPGVSNEAQYVFTIQSIVMAQKLKGTLSFIAKNDEGATHEKLDFRLHFSCSSYLITTPCYSDAFAKLLESGDLSMSSIKVDGIRMSFQNLLAKICFHHHFSVVERVDSCASMYSRSIQGHHVCLLVKKGENSVSVDGKCSDSTLLSNLLEEMKATLAKC
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O14617 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| K4 | Ubiquitination | Uniprot | |
| K7 | Ubiquitination | Uniprot | |
| S9 | Phosphorylation | Uniprot | |
| K16 | Ubiquitination | Uniprot | |
| K34 | Ubiquitination | Uniprot | |
| K44 | Ubiquitination | Uniprot | |
| K55 | Ubiquitination | Uniprot | |
| K164 | Ubiquitination | Uniprot | |
| K165 | Ubiquitination | Uniprot | |
| K176 | Acetylation | Uniprot | |
| K176 | Ubiquitination | Uniprot | |
| S180 | Phosphorylation | Uniprot | |
| K191 | Ubiquitination | Uniprot | |
| T270 | Phosphorylation | Uniprot | |
| K332 | Ubiquitination | Uniprot | |
| K336 | Ubiquitination | Uniprot | |
| K342 | Ubiquitination | Uniprot | |
| K352 | Ubiquitination | Uniprot | |
| S355 | Phosphorylation | Uniprot | |
| Y365 | Phosphorylation | Uniprot | |
| K379 | Ubiquitination | Uniprot | |
| K386 | Acetylation | Uniprot | |
| K584 | Ubiquitination | Uniprot | |
| K588 | Ubiquitination | Uniprot | |
| K610 | Ubiquitination | Uniprot | |
| K613 | Ubiquitination | Uniprot | |
| S632 | Phosphorylation | Uniprot | |
| S634 | Phosphorylation | Uniprot | |
| S636 | Phosphorylation | Uniprot | |
| S658 | Phosphorylation | Uniprot | |
| K673 | Ubiquitination | Uniprot | |
| Y682 | Phosphorylation | Uniprot | |
| S685 | Phosphorylation | Uniprot | |
| S686 | Phosphorylation | Uniprot | |
| S688 | Phosphorylation | Uniprot | |
| T696 | Phosphorylation | Uniprot | |
| S721 | Phosphorylation | Uniprot | |
| Y724 | Phosphorylation | Uniprot | |
| K736 | Acetylation | Uniprot | |
| S758 | Phosphorylation | Uniprot | |
| S759 | Phosphorylation | Uniprot | |
| T762 | Phosphorylation | Uniprot | |
| S764 | Phosphorylation | Uniprot | |
| T778 | Phosphorylation | Uniprot | |
| S788 | Phosphorylation | Uniprot | |
| Y799 | Phosphorylation | Uniprot | |
| K808 | Ubiquitination | Uniprot | |
| K820 | Ubiquitination | Uniprot | |
| T824 | Phosphorylation | Uniprot | |
| T826 | Phosphorylation | Uniprot | |
| S827 | Phosphorylation | Uniprot | |
| S829 | Phosphorylation | Uniprot | |
| S869 | Phosphorylation | Uniprot | |
| S1070 | Phosphorylation | Uniprot | |
| S1071 | Phosphorylation | Uniprot | |
| C1103 | S-Nitrosylation | Uniprot | |
| K1132 | Ubiquitination | Uniprot |
研究背景
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity).
Cytoplasm. Golgi apparatus membrane>Peripheral membrane protein>Cytoplasmic side.
Present in all adult tissues examined with the highest levels in skeletal muscle, heart, pancreas and testis.
AP-3 associates with the BLOC-1 complex (By similarity). Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2) (By similarity). Interacts with SLC30A2.
Belongs to the adaptor complexes large subunit family.
研究領域
· Cellular Processes > Transport and catabolism > Lysosome. (View pathway)
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