ASIC2 Antibody - #DF12840
| 製品: | ASIC2 Antibody |
| カタログ: | DF12840 |
| タンパク質の説明: | Rabbit polyclonal antibody to ASIC2 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Bovine, Rabbit, Dog, Chicken |
| 分子量: | 70 kDa; 58kD(Calculated). |
| ユニプロット: | Q16515 |
| RRID: | AB_2845801 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12840, RRID:AB_2845801.
折りたたみ／展開
ACCN; ACCN1; ACCN1_HUMAN; Acid sensing ion channel 2; Acid-sensing ion channel 2; Amiloride sensitive brain sodium channel; Amiloride sensitive cation channel 1 neuronal (degenerin); Amiloride sensitive cation channel 1 neuronal; Amiloride-sensitive brain sodium channel; Amiloride-sensitive cation channel 1, neuronal; Amiloride-sensitive cation channel neuronal 1; ASIC2; ASIC2a; BNaC1; BNC1; Brain sodium channel 1; Degenerin; hBNaC1; Mammalian degenerin homolog; MDEG; Neuronal amiloride sensitive cation channel 1;
免疫原
Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary.
- Q16515 ASIC2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDLKESPSEGSLQPSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDPHLADPSVLEALRQKANFKHYKPKQFSMLEFLHRVGHDLKDMMLYCKFKGQECGHQDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEEDEGSHDENVSTCDTMPNHSETISHTVNVPLQTTLGTLEEIAC
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q16515 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T39 | Phosphorylation | Uniprot | |
| Y357 | Phosphorylation | Uniprot |
研究背景
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.
Cell membrane>Multi-pass membrane protein.
Note: Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes.
Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary.
Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with STOM; this regulates channel activity (By similarity). Interacts with PRKCABP and ASIC3. Heterotrimer of Asic1a-Asic2a interacts with the snake venom mambalgin-1. Heterotrimer of Asic1a-Asic2a interacts with the snake venom mambalgin-2 and mambalgin-3 (By similarity). Heterotrimer of Asic1a-Asic2b interacts with the snake venom mambalgin-1 and mambalgin-2 (By similarity).
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC2 subfamily.
研究領域
· Organismal Systems > Sensory system > Taste transduction.
· Organismal Systems > Sensory system > Inflammatory mediator regulation of TRP channels. (View pathway)
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