AXUD1 Antibody - #DF12847

(1)   (4)  
製品: AXUD1 Antibody
カタログ: DF12847
タンパク質の説明: Rabbit polyclonal antibody to AXUD1
アプリケーション: WB
反応性: Human, Mouse, Rat, Monkey
予測: Pig, Bovine, Sheep, Rabbit, Dog
分子量: 64 kDa; 64kD(Calculated).
ユニプロット: Q96S65
RRID: AB_2845808

類似製品を見る>>

   サイズ 価格 在庫状況
 100ul $280 在庫あり
 200ul $350 在庫あり

リードタイム: 当日配達

For pricing and ordering contact:
お問い合わせ先
関連ダウンロード
MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat,Monkey
予測:
Pig(100%), Bovine(100%), Sheep(100%), Rabbit(100%), Dog(100%)
クローナリティ:
Polyclonal
特異性:
AXUD1 Antibody detects endogenous levels of total AXUD1.
RRID:
AB_2845808
引用形式: Affinity Biosciences Cat# DF12847, RRID:AB_2845808.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

4931429D10Rik; Axin 1 Up-regulated; Axin-1 up-regulated gene 1 protein; CSRN1_HUMAN; CSRNP-1; CSRNP1; Cysteine/serine-rich nuclear protein 1; DKFZp566F164; FAM130B; Protein URAX1; TAIP 3; TAIP-3; TGF beta induced apoptosis protein 3; TGF-beta-induced apoptosis protein 3; URAX1;

免疫原

免疫原:
Uniprot:

Q96S65(CSRN1_HUMAN) >>Visit HPA database.

遺伝子(ID):
CSRNP1(64651)
発現特異性:
Q96S65 CSRN1_HUMAN:

Ubiquitous. Most abundantly expressed in lung, placenta, skeletal muscle, pancreas and leukocyte. Frequently down-regulated in lung, kidney, liver and colon cancers compared with their corresponding normal tissues.

タンパク質配列:
MTGLLKRKFDQLDEDNSSVSSSSSSSGCQSRSCSPSSSVSRAWDSEEEGPWDQMPLPDRDFCGPRSFTPLSILKRARRERPGRVAFDGITVFYFPRCQGFTSVPSRGGCTLGMALRHSACRRFSLAEFAQEQARARHEKLRQRLKEEKLEMLQWKLSAAGVPQAEAGLPPVVDAIDDASVEEDLAVAVAGGRLEEVSFLQPYPARRRRALLRASGVRRIDREEKRELQALRQSREDCGCHCDRICDPETCSCSLAGIKCQMDHTAFPCGCCREGCENPMGRVEFNQARVQTHFIHTLTRLQLEQEAESFRELEAPAQGSPPSPGEEALVPTFPLAKPPMNNELGDNSCSSDMTDSSTASSSASGTSEAPDCPTHPGLPGPGFQPGVDDDSLARILSFSDSDFGGEEEEEEEGSVGNLDNLSCFHPADIFGTSDPGGLASWTHSYSGCSFTSGVLDENANLDASCFLNGGLEGSREGSLPGTSVPPSMDAGRSSSVDLSLSSCDSFELLQALPDYSLGPHYTSQKVSDSLDNIEAPHFPLPGLSPPGDASSCFLESLMGFSEPAAEALDPFIDSQFEDTVPASLMEPVPV

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Xenopus
67
Chicken
50
Horse
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q96S65 基板として

Site PTM Type Enzyme
S25 Phosphorylation
S30 Phosphorylation
S32 Phosphorylation
S38 Phosphorylation
T68 Phosphorylation
S71 Phosphorylation
K74 Ubiquitination
R106 Methylation
T110 Phosphorylation

研究背景

機能:

Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis.

細胞の位置付け:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Ubiquitous. Most abundantly expressed in lung, placenta, skeletal muscle, pancreas and leukocyte. Frequently down-regulated in lung, kidney, liver and colon cancers compared with their corresponding normal tissues.

タンパク質ファミリー:

Belongs to the AXUD1 family.

参考文献

1). Matrine improves the hepatic microenvironment and reverses epithelial-mesenchymal transition in hepatocellular carcinoma by inhibiting the Wnt-1/β-catenin signaling pathway. American journal of translational research, 2023 (PubMed: 37692966) [IF=2.2]

Application: IHC    Species: Human    Sample: cirrhotic tissues and HCC tissues

Figure 1 Expression of the Wnt-1/β-catenin signaling pathway and EMT-associated proteins in cirrhotic tissues and HCC tissues as assessed by immunohistochemistry. A. Orange signal indicates the presence of Wnt-1, β-catenin, and Axin-1. Wnt-1 and Axin-1 were mainly present in the cytoplasm. β-Catenin was mainly expressed on the cell membrane in cirrhotic tissues and in the cytoplasm and nucleus in HCC tissues (magnification, 400×), P

Application: WB    Species: Human    Sample: cirrhotic tissues and HCC tissues

Figure 1 Expression of the Wnt-1/β-catenin signaling pathway and EMT-associated proteins in cirrhotic tissues and HCC tissues as assessed by immunohistochemistry. A. Orange signal indicates the presence of Wnt-1, β-catenin, and Axin-1. Wnt-1 and Axin-1 were mainly present in the cytoplasm. β-Catenin was mainly expressed on the cell membrane in cirrhotic tissues and in the cytoplasm and nucleus in HCC tissues (magnification, 400×), P

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.