BANP Antibody - #DF12849
| 製品: | BANP Antibody |
| カタログ: | DF12849 |
| タンパク質の説明: | Rabbit polyclonal antibody to BANP |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Rabbit, Dog, Chicken |
| 分子量: | 56 kDa; 56kD(Calculated). |
| ユニプロット: | Q8N9N5 |
| RRID: | AB_2845810 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12849, RRID:AB_2845810.
折りたたみ／展開
AAH09424; Banp; BANP_HUMAN; BEN domain-containing protein 1; BEND1; BTG3 associated nuclear protein isoform a; Btg3-associated nuclear protein; DKFZp761H172; FLJ 10177; FLJ 20538; FLJ10177; FLJ20538; Protein BANP; Scaffold/Matrix associated region 1; Scaffold/matrix-associated region-1-binding protein; SMAR 1; SMAR1; SMARBP 1; SMARBP1;
免疫原
- Q8N9N5 BANP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MMSEHDLADVVQIAVEDLSPDHPVVLENHVVTDEDEPALKRQRLEINCQDPSIKTICLRLDSIEAKLQALEATCKSLEEKLDLVTNKQHSPIQVPMVAGSPLGATQTCNKVRCVVPQTTVILNNDRQNAIVAKMEDPLSNRAPDSLENVISNAVPGRRQNTIVVKVPGQEDSHHEDGESGSEASDSVSSCGQAGSQSIGSNVTLITLNSEEDYPNGTWLGDENNPEMRVRCAIIPSDMLHISTNCRTAEKMALTLLDYLFHREVQAVSNLSGQGKHGKKQLDPLTIYGIRCHLFYKFGITESDWYRIKQSIDSKCRTAWRRKQRGQSLAVKSFSRRTPNSSSYCPSEPMMSTPPPASELPQPQPQPQALHYALANAQQVQIHQIGEDGQVQVGHLHIAQVPQGEQVQITQDSEGNLQIHHVGQDGQLLEATRIPCLLAPSVFKASSGQVLQGAQLIAVASSDPAAAGVDGSPLQGSDIQVQYVQLAPVSDHTAGAQTAEALQPTLQPEMQLEHGAIQIQ
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8N9N5 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S19 | Phosphorylation | Uniprot | |
| K75 | Ubiquitination | Uniprot | |
| K80 | Ubiquitination | Uniprot | |
| T85 | Phosphorylation | Uniprot | |
| K87 | Ubiquitination | Uniprot | |
| S90 | Phosphorylation | Uniprot | |
| S100 | Phosphorylation | Uniprot | |
| K133 | Ubiquitination | Uniprot | |
| S139 | Phosphorylation | Uniprot | |
| S145 | Phosphorylation | Uniprot | |
| S151 | Phosphorylation | Uniprot | |
| K275 | Ubiquitination | Uniprot | |
| K279 | Ubiquitination | Uniprot | |
| Y287 | Phosphorylation | Uniprot | |
| K308 | Ubiquitination | Uniprot | |
| R324 | Methylation | Uniprot | |
| S327 | Phosphorylation | Uniprot | |
| K331 | Ubiquitination | Uniprot | |
| T337 | Phosphorylation | P27361 (MAPK3) , P28482 (MAPK1) | Uniprot |
| T352 | Phosphorylation | P27361 (MAPK3) , P28482 (MAPK1) | Uniprot |
研究背景
Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity).
Nucleus.
Down-regulated in breast cancer cell lines.
Interacts with TP53 and CUX1/CDP (By similarity). Interacts with HDAC1. Part of a corepressor complex containing BANP, HDAC1, SIN3A, SIN3B, RBL1 and RBL2.
Belongs to the BANP/SMAR1 family.
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