BCAT1/ECA39 Antibody - #DF12850
| 製品: | BCAT1/ECA39 Antibody |
| カタログ: | DF12850 |
| タンパク質の説明: | Rabbit polyclonal antibody to BCAT1/ECA39 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 43 kDa; 43kD(Calculated). |
| ユニプロット: | P54687 |
| RRID: | AB_2845811 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12850, RRID:AB_2845811.
折りたたみ／展開
BCAT; BCAT(c); Bcat1; BCAT1_HUMAN; BCT1; Branched chain amino acid aminotransferase, cytosolic; branched chain amino-acid transaminase 1, cytosolic; branched chain aminotransferase 1; branched chain aminotransferase 1, cytosolic; Branched-chain-amino-acid aminotransferase; cytosolic; DKFZp686E12175; EC 2.6.1.42; ECA39; MECA39; placental protein 18; PNAS 121; PP18; Protein ECA39;
免疫原
During embryogenesis, expressed in the brain and kidney. Overexpressed in MYC-induced tumors such as Burkitt's lymphoma.
- P54687 BCAT1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKDCSNGCSAECTGEGGSKEVVGTFKAKDLIVTPATILKEKPDPNNLVFGTVFTDHMLTVEWSSEFGWEKPHIKPLQNLSLHPGSSALHYAVELFEGLKAFRGVDNKIRLFQPNLNMDRMYRSAVRATLPVFDKEELLECIQQLVKLDQEWVPYSTSASLYIRPTFIGTEPSLGVKKPTKALLFVLLSPVGPYFSSGTFNPVSLWANPKYVRAWKGGTGDCKMGGNYGSSLFAQCEAVDNGCQQVLWLYGEDHQITEVGTMNLFLYWINEDGEEELATPPLDGIILPGVTRRCILDLAHQWGEFKVSERYLTMDDLTTALEGNRVREMFGSGTACVVCPVSDILYKGETIHIPTMENGPKLASRILSKLTDIQYGREESDWTIVLS
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P54687 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| K2 | Ubiquitination | Uniprot | |
| S9 | Phosphorylation | Uniprot | |
| T13 | Phosphorylation | Uniprot | |
| S18 | Phosphorylation | Uniprot | |
| K19 | Ubiquitination | Uniprot | |
| K26 | Ubiquitination | Uniprot | |
| K28 | Ubiquitination | Uniprot | |
| Y90 | Phosphorylation | Uniprot | |
| K107 | Ubiquitination | Uniprot | |
| R119 | Methylation | Uniprot | |
| K134 | Acetylation | Uniprot | |
| K134 | Ubiquitination | Uniprot | |
| K215 | Ubiquitination | Uniprot | |
| K305 | Ubiquitination | Uniprot | |
| S331 | Phosphorylation | Uniprot | |
| T333 | Phosphorylation | Uniprot | |
| S341 | Phosphorylation | Uniprot | |
| Y345 | Phosphorylation | Uniprot | |
| K346 | Ubiquitination | Uniprot | |
| K360 | Ubiquitination | Uniprot | |
| K368 | Ubiquitination | Uniprot | |
| T370 | Phosphorylation | Uniprot |
研究背景
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
Cytoplasm.
During embryogenesis, expressed in the brain and kidney. Overexpressed in MYC-induced tumors such as Burkitt's lymphoma.
Homodimer.
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
研究領域
· Metabolism > Amino acid metabolism > Cysteine and methionine metabolism.
· Metabolism > Amino acid metabolism > Valine, leucine and isoleucine degradation.
· Metabolism > Amino acid metabolism > Valine, leucine and isoleucine biosynthesis.
· Metabolism > Metabolism of cofactors and vitamins > Pantothenate and CoA biosynthesis.
· Metabolism > Global and overview maps > Metabolic pathways.
· Metabolism > Global and overview maps > 2-Oxocarboxylic acid metabolism.
· Metabolism > Global and overview maps > Biosynthesis of amino acids.
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