CACNA1B Antibody - #DF12872
製品: | CACNA1B Antibody |
カタログ: | DF12872 |
ソース: | Rabbit |
アプリケーション: | WB |
反応性: | Human, Mouse, Rat |
予測: | Pig, Bovine, Horse, Rabbit, Dog |
分子量: | 262 kDa; 262kD(Calculated). |
ユニプロット: | Q00975 |
RRID: | AB_2845833 |
製品説明
*The optimal dilutions should be determined by the end user.
引用形式: Affinity Biosciences Cat# DF12872, RRID:AB_2845833.
免疫原
Isoform Alpha-1b-1 and isoform Alpha-1b-2 are expressed in the central nervous system, but not in skeletal muscle or aorta. Expressed in the cerebral white matter, cortex, hippocampus, basal ganglia, and cerebellum (PubMed:30982612).
- Q00975 CAC1B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVRFGDELGGRYGGPGGGERARGGGAGGAGGPGPGGLQPGQRVLYKQSIAQRARTMALYNPIPVKQNCFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATKKSRNDLIHAEEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAARQQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLDRPLVVELGRDGARGPVGGKARPEAAEAPEGVDPPRRHHRHRDKDKTPAAGDQDRAEAPKAESGEPGAREERPRPHRSHSKEAAGPPEARSERGRGPGPEGGRRHHRRGSPEEAAEREPRRHRAHRHQDPSKECAGAKGERRARHRGGPRAGPREAESGEEPARRHRARHKAQPAHEAVEKETTEKEATEKEAEIVEADKEKELRNHQPREPHCDLETSGTVTVGPMHTLPSTCLQKVEEQPEDADNQRNVTRMGSQPPDPNTIVHIPVMLTGPLGEATVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALEIKLAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLEQTQPAVLRGARVFLRQKSSTSLSNGGAIQNQESGIKESVSWGTQRTQDAPHEARPPLERGHSTEIPVGRSGALAVDVQMQSITRRGPDGEPQPGLESQGRAASMPRLAAETQPVTDASPMKRSISTLAQRPRGTHLCSTTPDRPPPSQASSHHHHHRCHRRRDRKQRSLEKGPSLSADMDGAPSSAVGPGLPPGEGPTGCRRERERRQERGRSQERRQPSSSSSEKQRFYSCDRFGGREPPKPKPSLSSHPTSPTAGQEPGPHPQGSGSVNGSPLLSTSGASTPGRGGRRQLPQTPLTPRPSITYKTANSSPIHFAGAQTSLPAFSPGRLSRGLSEHNALLQRDPLSQPLAPGSRIGSDPYLGQRLDSEASVHALPEDTLTFEEAVATNSGRSSRTSYVSSLTSQSHPLRRVPNGYHCTLGLSSGGRARHSYHHPDQDHWC
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q00975 基板として
Site | PTM Type | Enzyme | Source |
---|---|---|---|
S208 | Phosphorylation | Uniprot | |
Y245 | Phosphorylation | Uniprot | |
K374 | Ubiquitination | Uniprot | |
S411 | Phosphorylation | P28482 (MAPK1) , P27361 (MAPK3) | Uniprot |
T421 | Phosphorylation | Uniprot | |
S446 | Phosphorylation | P27361 (MAPK3) , P28482 (MAPK1) | Uniprot |
S455 | Phosphorylation | Uniprot | |
S761 | Phosphorylation | Uniprot | |
S766 | Phosphorylation | Uniprot | |
S971 | Phosphorylation | Uniprot | |
K1242 | Ubiquitination | Uniprot | |
K1248 | Ubiquitination | Uniprot | |
K1331 | Ubiquitination | Uniprot | |
S1445 | Phosphorylation | Uniprot | |
K1447 | Ubiquitination | Uniprot | |
T1450 | Phosphorylation | Uniprot | |
T1869 | Phosphorylation | Uniprot | |
T1870 | Phosphorylation | Uniprot | |
T1941 | Phosphorylation | Uniprot | |
T1944 | Phosphorylation | Uniprot | |
S1960 | Phosphorylation | Uniprot | |
S1968 | Phosphorylation | Uniprot | |
S2001 | Phosphorylation | Uniprot | |
T2009 | Phosphorylation | Uniprot | |
S2023 | Phosphorylation | Uniprot | |
T2024 | Phosphorylation | Uniprot | |
S2119 | Phosphorylation | Uniprot | |
S2120 | Phosphorylation | Q9UQM7 (CAMK2A) | Uniprot |
Y2128 | Phosphorylation | Uniprot | |
S2129 | Phosphorylation | P17612 (PRKACA) | Uniprot |
S2233 | Phosphorylation | Uniprot | |
S2256 | Phosphorylation | Uniprot | |
Y2259 | Phosphorylation | Uniprot | |
S2266 | Phosphorylation | Uniprot |
研究背景
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by omega-conotoxin-GVIA (AC P01522) (AC P01522) (By similarity). They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.
Phosphorylated in vitro by CaM-kinase II, PKA, PKC and CGPK.
Membrane>Multi-pass membrane protein.
Isoform Alpha-1b-1 and isoform Alpha-1b-2 are expressed in the central nervous system, but not in skeletal muscle or aorta. Expressed in the cerebral white matter, cortex, hippocampus, basal ganglia, and cerebellum.
Multisubunit complex consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts with RIMS1. Interacts with FMR1 (via C-terminus); this interaction induces a deacrease in the number of presynaptic functional CACNA1B channels at the cell surface. Interacts with the omega-conotoxin-GVIA (AC P01522) (By similarity).
Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1B subfamily.
研究領域
Research Fields:
· Environmental Information Processing > Signal transduction > .(View pathway)
· Environmental Information Processing > Signal transduction > .(View pathway)
· Human Diseases > Endocrine and metabolic diseases > .
· Human Diseases > Substance dependence > .
· Organismal Systems > Nervous system > .
· Organismal Systems > Nervous system > .(View pathway)
· Organismal Systems > Nervous system > .
· Organismal Systems > Nervous system > .
· Organismal Systems > Nervous system > .
· Organismal Systems > Nervous system > .
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