CCT4 Antibody - #DF12888

(2)  
製品: CCT4 Antibody
カタログ: DF12888
タンパク質の説明: Rabbit polyclonal antibody to CCT4
アプリケーション: WB
反応性: Human, Mouse, Rat
予測: Pig, Zebrafish, Bovine, Rabbit, Dog, Xenopus
分子量: 58 kDa, 50 kDa; 58kD(Calculated).
ユニプロット: P50991
RRID: AB_2845849

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(91%), Zebrafish(89%), Bovine(91%), Rabbit(100%), Dog(91%), Xenopus(100%)
クローナリティ:
Polyclonal
特異性:
CCT4 Antibody detects endogenous levels of total CCT4.
RRID:
AB_2845849
引用形式: Affinity Biosciences Cat# DF12888, RRID:AB_2845849.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

CCT delta; CCT4; CCTD; chaperonin containing t-complex polypeptide 1, delta subunit; chaperonin containing TCP1, subunit 4 (delta); SRB; Stimulator of TAR RNA binding; T complex protein 1 subunit delta; TCP-1-delta;

免疫原

免疫原:
Uniprot:

P50991(TCPD_HUMAN) >>Visit HPA database.

遺伝子(ID):
CCT4(10575)
タンパク質配列:
MPENVAPRSGATAGAAGGRGKGAYQDRDKPAQIRFSNISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVLHPAARMLVELSKAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKGIEILTDMSRPVELSDRETLLNSATTSLNSKVVSQYSSLLSPMSVNAVMKVIDPATATSVDLRDIKIVKKLGGTIDDCELVEGLVLTQKVSNSGITRVEKAKIGLIQFCLSAPKTDMDNQIVVSDYAQMDRVLREERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFLNKMKIMVIKDIEREDIEFICKTIGTKPVAHIDQFTADMLGSAELAEEVNLNGSGKLLKITGCASPGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTLSGMESYCVRAFADAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTAGINVRKGGISNILEELVVQPLLVSVSALTLATETVRSILKIDDVVNTR

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Rabbit
100
Xenopus
100
Pig
91
Bovine
91
Dog
91
Zebrafish
89
Horse
0
Sheep
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P50991 基板として

Site PTM Type Enzyme
R8 Methylation
S9 Phosphorylation
R19 Methylation
K21 Methylation
Y24 Phosphorylation
R27 Methylation
K29 Ubiquitination
S36 Phosphorylation
K42 Ubiquitination
R49 Methylation
K55 Acetylation
K55 Ubiquitination
K59 Ubiquitination
K65 Acetylation
K65 Ubiquitination
K79 Ubiquitination
S95 Phosphorylation
K126 Ubiquitination
K139 Acetylation
K139 Methylation
K139 Ubiquitination
K143 Ubiquitination
S158 Phosphorylation
R160 Methylation
S170 Phosphorylation
S180 Phosphorylation
S184 Phosphorylation
T199 Phosphorylation
T201 Phosphorylation
S202 Phosphorylation
R206 Methylation
K209 Sumoylation
K213 Ubiquitination
K232 Ubiquitination
S234 Phosphorylation
S236 Phosphorylation
K243 Ubiquitination
K245 Ubiquitination
S254 Phosphorylation
S267 Phosphorylation
Y269 Phosphorylation
R274 Methylation
K288 Acetylation
K288 Ubiquitination
K292 Ubiquitination
C295 S-Nitrosylation
K302 Acetylation
K302 Ubiquitination
K319 Acetylation
K319 Ubiquitination
K321 Acetylation
K326 Acetylation
K343 Ubiquitination
K375 Ubiquitination
C379 S-Nitrosylation
S381 Phosphorylation
K384 Ubiquitination
T385 Phosphorylation
S393 Phosphorylation
K395 Acetylation
K395 Ubiquitination
C410 S-Nitrosylation
S444 Phosphorylation
Y449 Phosphorylation
S463 Phosphorylation
T464 Phosphorylation
K489 Acetylation
K489 Ubiquitination
K531 Ubiquitination
T538 Phosphorylation

研究背景

機能:

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin (Probable).

細胞の位置付け:

Cytoplasm. Melanosome. Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome. Cytoplasm>Cytoskeleton>Cilium basal body.
Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
サブユニット構造:

Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Interacts with DNAAF4 (By similarity).

タンパク質ファミリー:

Belongs to the TCP-1 chaperonin family.

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