CNKSR3 Antibody - #DF12901
| 製品: | CNKSR3 Antibody |
| カタログ: | DF12901 |
| タンパク質の説明: | Rabbit polyclonal antibody to CNKSR3 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 62 kDa; 62kD(Calculated). |
| ユニプロット: | Q6P9H4 |
| RRID: | AB_2845862 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12901, RRID:AB_2845862.
折りたたみ／展開
CNK homolog protein 3; CNK3; CNKSR family member 3; Connector enhancer of kinase suppressor of ras 3; Connector enhancer of KSR 3; MAGI1; Maguin like protein; Membrane associated guanylate kinase interacting protein like 1; Membrane associated guanylate kinase, WW and PDZ domain containing 1; RP11 486M3 1; RP11 486M3.1;
免疫原
- Q6P9H4 CNKR3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEPVTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYISSRRKSPAYDGNTSRKAPNEFLTSVVELIGAAKALLAWLDRAPFTGITDFSVTKNKIIQLCLDLTTTVQKDCFVAEMEDKVLTVVKVLNGICDKTIRSTTDPVMSQCACLEEVHLPNIKPGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVKKLRENPTGVVLLLKKRPTGSFNFTPAPLKNLRWKPPLVQTSPPPATTQSPESTMDTSLKKEKSAILDLYIPPPPAVPYSPRDENGSFVYGGSSKCKQPLPGPKGSESPNSFLDQESRRRRFTIADSDQLPGYSVETNILPTKMREKTPSYGKPRPLSMPADGNWMGIVDPFARPRGHGRKGEDALCRYFSNERIPPIIEESSSPPYRFSRPTTERHLVRGADYIRGSRCYINSDLHSSATIPFQEEGTKKKSGSSATKSSSTEPSLLVSWFTRLKLLTH
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q6P9H4 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K34 | Ubiquitination | Uniprot | |
| S105 | Phosphorylation | Uniprot | |
| S113 | Phosphorylation | Uniprot | |
| T283 | Phosphorylation | Uniprot | |
| T300 | Phosphorylation | Uniprot | |
| K305 | Ubiquitination | Uniprot | |
| S325 | Phosphorylation | Uniprot | |
| S339 | Phosphorylation | Uniprot | |
| S355 | Phosphorylation | Uniprot | |
| Y365 | Phosphorylation | Uniprot | |
| S381 | Phosphorylation | Uniprot | |
| S383 | Phosphorylation | Uniprot | |
| T398 | Phosphorylation | Uniprot | |
| Y426 | Phosphorylation | Uniprot | |
| S433 | Phosphorylation | Uniprot | |
| S466 | Phosphorylation | Uniprot | |
| S479 | Phosphorylation | Uniprot | |
| R483 | Methylation | Uniprot | |
| R495 | Methylation | Uniprot | |
| S503 | Phosphorylation | Uniprot | |
| S514 | Phosphorylation | Uniprot | |
| S545 | Phosphorylation | Uniprot |
研究背景
Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC-regulatory complex (ERC).
Cytoplasm. Apical cell membrane>Peripheral membrane protein.
Interacts with epithelial sodium channel ENaC. Interacts directly with SCNN1A (ENaC subunit alpha) and SCNN1B (ENaC subunit beta) C-terminal tails. Interacts with ENaC regulatory proteins NEDD4L, RAF1 and SGK1.
The PDZ domain is required for interaction with ENaC and SGK1, but not for interaction with NEDDL4 and RAF1.
Belongs to the CNKSR family.
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