COPG2 Antibody - #DF12908
| 製品: | COPG2 Antibody |
| カタログ: | DF12908 |
| タンパク質の説明: | Rabbit polyclonal antibody to COPG2 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse |
| 予測: | Zebrafish, Chicken |
| 分子量: | 98 kDa; 98kD(Calculated). |
| ユニプロット: | Q9UBF2 |
| RRID: | AB_2845869 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12908, RRID:AB_2845869.
折りたたみ／展開
2 COP; Coat protein nonclathrin gamma 2 cop; Coatomer protein complex subunit gamma 2; Coatomer subunit gamma 2; Coatomer subunit gamma-2; COPG 2; Copg2; COPG2_HUMAN; DKFZp761N09121; FLJ11781; Gamma 2 coat protein; Gamma 2 COP; Gamma-2-coat protein; Gamma-2-COP;
免疫原
- Q9UBF2 COPG2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MIKKFDKKDEESGSGSNPFQHLEKSAVLQEARIFNETPINPRRCLHILTKILYLLNQGEHFGTTEATEAFFAMTRLFQSNDQTLRRMCYLTIKEMATISEDVIIVTSSLTKDMTGKEDVYRGPAIRALCRITDGTMLQAIERYMKQAIVDKVSSVSSSALVSSLHMMKISYDVVKRWINEAQEAASSDNIMVQYHALGVLYHLRKNDRLAVSKMLNKFTKSGLKSQFAYCMLIRIASRLLKETEDGHESPLFDFIESCLRNKHEMVIYEAASAIIHLPNCTARELAPAVSVLQLFCSSPKPALRYAAVRTLNKVAMKHPSAVTACNLDLENLITDSNRSIATLAITTLLKTGSESSVDRLMKQISSFVSEISDEFKVVVVQAISALCQKYPRKHSVMMTFLSNMLRDDGGFEYKRAIVDCIISIVEENPESKEAGLAHLCEFIEDCEHTVLATKILHLLGKEGPRTPVPSKYIRFIFNRVVLENEAVRAAAVSALAKFGAQNESLLPSILVLLQRCMMDTDDEVRDRATFYLNVLQQRQMALNATYIFNGLTVSVPGMEKALHQYTLEPSEKPFDMKSIPLAMAPVFEQKAEITLVATKPEKLAPSRQDIFQEQLAAIPEFLNIGPLFKSSEPVQLTEAETEYFVRCIKHMFTNHIVFQFDCTNTLNDQLLEKVTVQMEPSDSYEVLSCIPAPSLPYNQPGICYTLVRLPDDDPTAVAGSFSCTMKFTVRDCDPNTGVPDEDGYDDEYVLEDLEVTVSDHIQKVLKPNFAAAWEEVGDTFEKEETFALSSTKTLEEAVNNIITFLGMQPCERSDKVPENKNSHSLYLAGIFRGGYDLLVRSRLALADGVTMQVTVRSKERTPVDVILASVG
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9UBF2 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S12 | Phosphorylation | Uniprot | |
| K24 | Ubiquitination | Uniprot | |
| S25 | Phosphorylation | Uniprot | |
| R32 | Methylation | Uniprot | |
| T67 | Phosphorylation | Uniprot | |
| S99 | Phosphorylation | Uniprot | |
| Y143 | Phosphorylation | Uniprot | |
| K145 | Methylation | Uniprot | |
| K145 | Ubiquitination | Uniprot | |
| Y229 | Phosphorylation | Uniprot | |
| S249 | Phosphorylation | Uniprot | |
| S257 | Phosphorylation | Uniprot | |
| C296 | S-Nitrosylation | Uniprot | |
| C325 | S-Nitrosylation | Uniprot | |
| S339 | Phosphorylation | Uniprot | |
| S366 | Phosphorylation | Uniprot | |
| K461 | Ubiquitination | Uniprot | |
| K471 | Ubiquitination | Uniprot | |
| Y472 | Phosphorylation | Uniprot | |
| K572 | Ubiquitination | Uniprot | |
| K599 | Ubiquitination | Uniprot | |
| K602 | Ubiquitination | Uniprot | |
| T637 | Phosphorylation | Uniprot | |
| K766 | Ubiquitination | Uniprot | |
| K782 | Ubiquitination | Uniprot | |
| Y826 | Phosphorylation | Uniprot | |
| Y835 | Phosphorylation | Uniprot | |
| T850 | Phosphorylation | Uniprot | |
| T854 | Phosphorylation | Uniprot | |
| S857 | Phosphorylation | Uniprot |
研究背景
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).
Cytoplasm>Cytosol. Golgi apparatus membrane>Peripheral membrane protein>Cytoplasmic side. Cytoplasmic vesicle>COPI-coated vesicle membrane>Peripheral membrane protein>Cytoplasmic side.
Note: The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Tends to be more abundant in the trans-Golgi network compared to the cis-Golgi.
Oligomeric complex. Binds to CDC42. Interacts with JAGN1.
Belongs to the COPG family.
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