製品: DCP1B Antibody
カタログ: DF12929
タンパク質の説明: Rabbit polyclonal antibody to DCP1B
アプリケーション: WB
反応性: Human, Mouse, Rat
予測: Horse
分子量: 68 kDa; 68kD(Calculated).
ユニプロット: Q8IZD4
RRID: AB_2845890

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Horse(83%)
クローナリティ:
Polyclonal
特異性:
DCP1B Antibody detects endogenous levels of total DCP1B.
RRID:
AB_2845890
引用形式: Affinity Biosciences Cat# DF12929, RRID:AB_2845890.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

DCP 1B; DCP1; DCP1 decapping enzyme homolog B; DCP1B; DCP1B_HUMAN; Decapping enzyme Dcp1b; Decapping enzyme hDcp1b; Decapping enzyme homolog B (S. cerevisiae); Decapping mRNA 1B; hDcp1b; mRNA decapping enzyme 1B; mRNA-decapping enzyme 1B;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
タンパク質配列:
MAAVAAGGLVGKGRDISLAALQRHDPYINRIVDVASQVALYTFGHRANEWEKTDVEGTLFVYTRSASPKHGFTIMNRLSMENRTEPITKDLDFQLQDPFLLYRNARLSIYGIWFYDKEECQRIAELMKNLTQYEQLKAHQGTGAGISPVILNSGEGKEVDILRMLIKAKDEYTKCKTCSEPKKITSSSAIYDNPNLIKPIPVKPSENQQQRIPQPNQTLDPEPQHLSLTALFGKQDKATCQETVEPPQTLHQQQQQQQQQQEKLPIRQGVVRSLSYEEPRRHSPPIEKQLCPAIQKLMVRSADLHPLSELPENRPCENGSTHSAGEFFTGPVQPGSPHNIGTSRGVQNASRTQNLFEKLQSTPGAANKCDPSTPAPASSAALNRSRAPTSVTPVAPGKGLAQPPQAYFNGSLPPQTVGHQAHGREQSTLPRQTLPISGSQTGSSGVISPQELLKKLQIVQQEQQLHASNRPALAAKFPVLAQSSGTGKPLESWINKTPNTEQQTPLFQVISPQRIPATAAPSLLMSPMVFAQPTSVPPKERESGLLPVGGQEPPAAATSLLLPIQSPEPSVITSSPLTKLQLQEALLYLIQNDDNFLNIIYEAYLFSMTQAAMKKTM

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Horse
83
Pig
58
Dog
58
Bovine
56
Sheep
56
Rabbit
55
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q8IZD4 基板として

Site PTM Type Enzyme
A2 Acetylation
K12 Ubiquitination
S67 Phosphorylation
K69 Ubiquitination
K89 Ubiquitination
Y110 Phosphorylation
K128 Ubiquitination
Y133 Phosphorylation
K137 Ubiquitination
T142 Phosphorylation
S147 Phosphorylation
K157 Ubiquitination
Y172 Phosphorylation
T173 Phosphorylation
K183 Ubiquitination
S186 Phosphorylation
S187 Phosphorylation
S188 Phosphorylation
Y191 Phosphorylation
K198 Ubiquitination
S227 Phosphorylation
T229 Phosphorylation
K234 Ubiquitination
S275 Phosphorylation
Y276 Phosphorylation
S283 Phosphorylation
S336 Phosphorylation
K358 Ubiquitination
T362 Phosphorylation
S372 Phosphorylation
T373 Phosphorylation
S385 Phosphorylation
T392 Phosphorylation
S448 Phosphorylation
K455 Ubiquitination
K488 Ubiquitination
T504 Phosphorylation
S511 Phosphorylation
S566 Phosphorylation

研究背景

機能:

May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity).

細胞の位置付け:

Cytoplasm. Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
サブユニット構造:

Binds DCP1A. Part of a complex containing enzymes involved in mRNA decay, including DCP2, LSM1, LSM3 and CNOT6.

タンパク質ファミリー:

Belongs to the DCP1 family.

研究領域

· Genetic Information Processing > Folding, sorting and degradation > RNA degradation.

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