DDX6 Antibody - #DF12937
| 製品: | DDX6 Antibody |
| カタログ: | DF12937 |
| タンパク質の説明: | Rabbit polyclonal antibody to DDX6 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 54 kDa; 54kD(Calculated). |
| ユニプロット: | P26196 |
| RRID: | AB_2845898 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12937, RRID:AB_2845898.
折りたたみ／展開
ATP dependent RNA helicase DDX6; ATP dependent RNA helicase p54; DDX6; DEAD (Asp Glu Ala Asp) box polypeptide 6; DEAD box 6; DEAD box protein 6; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 6 (RNA helicase 54kD); FLJ36338; HLR2; Oncogene RCK; P54; Probable ATP-dependent RNA helicase DDX6; RCK;
免疫原
- P26196 DDX6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSTARTENPVIMGLSSQNGQLRGPVKPTGGPGGGGTQTQQQMNQLKNTNTINNGTQQQAQSMTTTIKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPSPIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQVSQICIQVSKHMGGAKVMATTGGTNLRDDIMRLDDTVHVVIATPGRILDLIKKGVAKVDHVQMIVLDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPLSVQKFMNSHLQKPYEINLMEELTLKGVTQYYAYVTERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYSCFYIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLHRIGRSGRFGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVAEYHSEPVEDEKP
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P26196 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S15 | Phosphorylation | Uniprot | |
| S16 | Phosphorylation | Uniprot | |
| K26 | Ubiquitination | Uniprot | |
| T36 | Phosphorylation | Uniprot | |
| T38 | Phosphorylation | Uniprot | |
| T64 | Phosphorylation | Uniprot | |
| K67 | Acetylation | Uniprot | |
| K67 | Ubiquitination | Uniprot | |
| K73 | Acetylation | Uniprot | |
| K73 | Ubiquitination | Uniprot | |
| K74 | Acetylation | Uniprot | |
| T75 | Phosphorylation | Uniprot | |
| K81 | Ubiquitination | Uniprot | |
| K86 | Ubiquitination | Uniprot | |
| T87 | Phosphorylation | Uniprot | |
| K94 | Ubiquitination | Uniprot | |
| K104 | Acetylation | Uniprot | |
| K104 | Ubiquitination | Uniprot | |
| K146 | Ubiquitination | Uniprot | |
| S147 | Phosphorylation | Uniprot | |
| K162 | Ubiquitination | Uniprot | |
| K195 | Ubiquitination | Uniprot | |
| T199 | Phosphorylation | Uniprot | |
| K231 | Ubiquitination | Uniprot | |
| Y312 | Phosphorylation | Uniprot | |
| Y313 | Phosphorylation | Uniprot | |
| C324 | S-Nitrosylation | Uniprot | |
| T327 | Phosphorylation | Uniprot | |
| S330 | Phosphorylation | Uniprot | |
| R375 | Methylation | Uniprot | |
| T439 | Phosphorylation | Uniprot | |
| Y440 | Phosphorylation | Uniprot | |
| K447 | Ubiquitination | Uniprot | |
| K458 | Ubiquitination | Uniprot | |
| S462 | Phosphorylation | Uniprot | |
| K466 | Ubiquitination | Uniprot | |
| Y473 | Phosphorylation | Uniprot | |
| S475 | Phosphorylation | Uniprot | |
| K482 | Ubiquitination | Uniprot |
研究背景
In the process of mRNA degradation, plays a role in mRNA decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts.
Sumoylated.
Cytoplasm>P-body. Cytoplasm. Nucleus.
Note: Upon cellular stress, relocalizes to stress granules (PubMed:26184334).
Abundantly expressed in most tissues.
Forms a complex with DCP1A, DCP2, EDC3 and EDC4/HEDLS. Interacts with LIMD1, WTIP and AJUBA. Interacts with APOBEC3G in an RNA-dependent manner. Interacts with RC3H1 (By similarity). Interacts with ATXN2L. Interacts with MCRIP1. Interacts with MCRIP2. Interacts with NUFIP2. Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner.
Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
研究領域
· Genetic Information Processing > Folding, sorting and degradation > RNA degradation.
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