DIO2 Antibody - #DF12941
| 製品: | DIO2 Antibody |
| カタログ: | DF12941 |
| タンパク質の説明: | Rabbit polyclonal antibody to DIO2 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Rabbit, Dog, Chicken |
| 分子量: | 31 kDa; 31kD(Calculated). |
| ユニプロット: | Q92813 |
| RRID: | AB_2845902 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12941, RRID:AB_2845902.
折りたたみ／展開
5DII; D2; Deiodinase, iodothyronine, type II; DIO2; DIOII; EC 1.97.1.10; IOD2_HUMAN; ITDI2; SelY; Thyroxine deiodinase, type II; TXDI2; Type 2 DI; Type 2 iodothyronine deiodinase; Type II 5' deiodinase; Type II iodothyronine deiodinase; Type-II 5''-deiodinase;
免疫原
A synthesized peptide derived from human DIO2, corresponding to a region within N-terminal amino acids.
Isoform 1 is expressed in the lung, trachea, kidney, heart, skeletal muscle, placenta, fetal brain and several regions of the adult brain (PubMed:8755651, PubMed:11165050). Isoform 2 is expressed in the brain, heart, kidney and trachea (PubMed:11165050).
- Q92813 IOD2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDAYKQVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASPERPLVVNFGSATUPPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSFEVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVRHWLEKNFSKRUKKTRLAG
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
研究背景
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.
Ubiquitinated by MARCHF6, leading to its degradation by the proteasome. Deubiquitinated by USP20 and USP33.
Membrane>Single-pass membrane protein.
Isoform 1 is expressed in the lung, trachea, kidney, heart, skeletal muscle, placenta, fetal brain and several regions of the adult brain. Isoform 2 is expressed in the brain, heart, kidney and trachea.
Interacts with USP20 and USP33. Interacts with MARCHF6.
Belongs to the iodothyronine deiodinase family.
研究領域
· Organismal Systems > Endocrine system > Thyroid hormone signaling pathway. (View pathway)
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