DKK2 Antibody - #DF12942
| 製品: | DKK2 Antibody |
| カタログ: | DF12942 |
| タンパク質の説明: | Rabbit polyclonal antibody to DKK2 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 32 kDa; 28kD(Calculated). |
| ユニプロット: | Q9UBU2 |
| RRID: | AB_2845903 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12942, RRID:AB_2845903.
折りたたみ／展開
Dickkopf 2; Dickkopf gene 2; Dickkopf homolog 2; Dickkopf related protein 2; Dickkopf WNT signaling pathway inhibitor 2; Dickkopf-2; Dickkopf-related protein 2; Dickkopf2; DKK 2; Dkk-2; Dkk2; DKK2_HUMAN; hDkk 2; hDkk-2; hDkk2;
免疫原
- Q9UBU2 DKK2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAALMRSKDSSCCLLLLAAVLMVESSQIGSSRAKLNSIKSSLGGETPGQAANRSAGMYQGLAFGGSKKGKNLGQAYPCSSDKECEVGRYCHSPHQGSSACMVCRRKKKRCHRDGMCCPSTRCNNGICIPVTESILTPHIPALDGTRHRDRNHGHYSNHDLGWQNLGRPHTKMSHIKGHEGDPCLRSSDCIEGFCCARHFWTKICKPVLHQGEVCTKQRKKGSHGLEIFQRCDCAKGLSCKVWKDATYSSKARLHVCQKI
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9UBU2 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y58 | Phosphorylation | Uniprot | |
| Y89 | Phosphorylation | Uniprot | |
| S92 | Phosphorylation | Uniprot | |
| S97 | Phosphorylation | Uniprot | |
| S98 | Phosphorylation | Uniprot | |
| Y155 | Phosphorylation | Uniprot | |
| S156 | Phosphorylation | Uniprot | |
| K250 | Acetylation | Uniprot |
研究背景
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
May be proteolytically processed by a furin-like protease.
Secreted.
Expressed in heart, brain, skeletal muscle and lung.
Interacts with LRP5 and LRP6.
The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
Belongs to the dickkopf family.
研究領域
· Environmental Information Processing > Signal transduction > Wnt signaling pathway. (View pathway)
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