DTX4 Antibody - #DF12963
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| 製品: | DTX4 Antibody |
| カタログ: | DF12963 |
| タンパク質の説明: | Rabbit polyclonal antibody to DTX4 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 67 kDa; 67kD(Calculated). |
| ユニプロット: | Q9Y2E6 |
| RRID: | AB_2845924 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12963, RRID:AB_2845924.
折りたたみ／展開
Deltex4; Dtx4; DTX4_HUMAN; E3 ubiquitin-protein ligase DTX4; Protein deltex-4; RING finger protein 155; RNF155;
免疫原
- Q9Y2E6 DTX4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLLASAVVVWEWLNEHGRWRPYSPAVSHHIEAVVRAGPRAGGSVVLGQVDSRLAPYIIDLQSMNQFRQDTGTLRPVRRNYYDPSSAPGKGVVWEWENDNGSWTPYDMEVGITIQHAYEKQHPWIDLTSIGFSYVIDFNTMGQINRQTQRQRRVRRRLDLIYPMVTGTLPKAQSWPVSPGPATSPPMSPCSCPQCVLVMSVKAAVVNGSTGPLQLPVTRKNMPPPGVVKLPPLPGSGAKPLDSTGTIRGPLKTAPSQVIRRQASSMPTGTTMGSPASPPGPNSKTGRVALATLNRTNLQRLAIAQSRVLIASGVPTVPVKNLNGSSPVNPALAGITGILMSAAGLPVCLTRPPKLVLHPPPVSKSEIKSIPGVSNTSRKTTKKQAKKGKTPEEVLKKYLQKVRHPPDEDCTICMERLTAPSGYKGPQPTVKPDLVGKLSRCGHVYHIYCLVAMYNNGNKDGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHSLPGHPDCKTIRIIYSIPPGIQGPEHPNPGKSFSARGFPRHCYLPDSEKGRKVLKLLLVAWDRRLIFAIGTSSTTGESDTVIWNEVHHKTEFGSNLTGHGYPDANYLDNVLAELAAQGISEDSTAQEKD
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9Y2E6 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T243 | Phosphorylation | Uniprot | |
| T245 | Phosphorylation | Uniprot | |
| T270 | Phosphorylation | Uniprot | |
| S311 | Phosphorylation | Uniprot | |
| T315 | Phosphorylation | Uniprot | |
| S376 | Phosphorylation | Uniprot | |
| Y447 | Phosphorylation | Uniprot | |
| Y453 | Phosphorylation | Uniprot | |
| Y505 | Phosphorylation | Uniprot | |
| S506 | Phosphorylation | Uniprot |
研究背景
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4.
Cytoplasm.
Interacts with NLRP4.
The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.
Belongs to the Deltex family.
研究領域
· Environmental Information Processing > Signal transduction > Notch signaling pathway. (View pathway)
参考文献
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