EPCR Antibody - #DF12980

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製品: EPCR Antibody
カタログ: DF12980
タンパク質の説明: Rabbit polyclonal antibody to EPCR
アプリケーション: WB IF/ICC
反応性: Human, Mouse, Rat
分子量: 49 kDa; 27kD(Calculated).
ユニプロット: Q9UNN8
RRID: AB_2845941

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MS Report
HPLC Report
MSDS
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WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
クローナリティ:
Polyclonal
特異性:
EPCR Antibody detects endogenous levels of total EPCR.
RRID:
AB_2845941
引用形式: Affinity Biosciences Cat# DF12980, RRID:AB_2845941.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Activated protein C receptor; APC receptor; APCR; bA42O4.2; CCCA; CCD41; CD201; CD201 antigen; cell cycle, centrosome-associated protein; Cell cycle, centrosome-associated protein; centrocyclin; Endothelial cell protein C receptor; Endothelial protein C receptor; EPCR; EPCR_HUMAN; MGC23024; PROCR; Protein C receptor, endothelial;

免疫原

免疫原:
Uniprot:

Q9UNN8(EPCR_HUMAN) >>Visit HPA database.

遺伝子(ID):
PROCR(10544)
発現特異性:
Q9UNN8 EPCR_HUMAN:

Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.

タンパク質配列:
MLTTLLPILLLSGWAFCSQDASDGLQRLHMLQISYFRDPYHVWYQGNASLGGHLTHVLEGPDTNTTIIQLQPLQEPESWARTQSGLQSYLLQFHGLVRLVHQERTLAFPLTIRCFLGCELPPEGSRAHVFFEVAVNGSSFVSFRPERALWQADTQVTSGVVTFTLQQLNAYNRTRYELREFLEDTCVQYVQKHISAENTKGSQTSRSYTSLVLGVLVGSFIIAGVAVGIFLCTGGRRC

PTMs - Q9UNN8 基板として

Site PTM Type Enzyme
N47 N-Glycosylation
N136 N-Glycosylation
N172 N-Glycosylation
S195 Phosphorylation
T204 Phosphorylation

研究背景

機能:

Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.

PTMs:

N-glycosylated.

A soluble form exists; probably released by a metalloprotease. Seems to have the same activity as the membrane-bound form.

細胞の位置付け:

Membrane>Single-pass type I membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.

研究領域

· Organismal Systems > Immune system > Complement and coagulation cascades.   (View pathway)

参考文献

1). Identification of endothelial protein C receptor as a novel druggable agonistic target for reendothelialization promotion and thrombosis prevention of eluting stent. Bioactive Materials, 2024 [IF=18.9]

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