FTCD Antibody - #DF13022
| 製品: | FTCD Antibody |
| カタログ: | DF13022 |
| タンパク質の説明: | Rabbit polyclonal antibody to FTCD |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 53 kDa; 59kD(Calculated). |
| ユニプロット: | O95954 |
| RRID: | AB_2845983 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF13022, RRID:AB_2845983.
折りたたみ／展開
Formimidoyltetrahydrofolate cyclodeaminase; Formimidoyltransferase cyclodeaminase; Formiminotetrahydrofolate cyclodeaminase; Formiminotransferase cyclodeaminase; Formiminotransferase-cyclodeaminase; FTCD; FTCD_HUMAN; Glutamate formiminotransferase; Glutamate formyltransferase; LCHC 1; LCHC1; 58K Golgi protein;
免疫原
- O95954 FTCD_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYTFVGPPECVVEGALNAARVASRLIDMSRHQGEHPRMGALDVCPFIPVRGVSVDECVLCAQAFGQRLAEELDVPVYLYGEAARMDSRRTLPAIRAGEYEALPKKLQQADWAPDFGPSSFVPSWGATATGARKFLIAFNINLLGTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLDEKNLAQVSTNLLDFEVTALHTVYEETCREAQELSLPVVGSQLVGLVPLKALLDAAAFYCEKENLFILEEEQRIRLVVSRLGLDSLCPFSPKERIIEYLVPERGPERGLGSKSLRAFVGEVGARSAAPGGGSVAAAAAAMGAALGSMVGLMTYGRRQFQSLDTTMRRLIPPFREASAKLTTLVDADAEAFTAYLEAMRLPKNTPEEKDRRTAALQEGLRRAVSVPLTLAETVASLWPALQELARCGNLACRSDLQVAAKALEMGVFGAYFNVLINLRDITDEAFKDQIHHRVSSLLQEAKTQAALVLDCLETRQE
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O95954 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y124 | Phosphorylation | Uniprot | |
| Y146 | Phosphorylation | Uniprot | |
| Y225 | Phosphorylation | Uniprot | |
| Y250 | Phosphorylation | Uniprot | |
| S316 | Phosphorylation | Uniprot | |
| Y324 | Phosphorylation | Uniprot | |
| S358 | Phosphorylation | Uniprot | |
| R381 | Methylation | Uniprot | |
| S386 | Phosphorylation | Uniprot | |
| R399 | Methylation | Uniprot | |
| S402 | Phosphorylation | Uniprot | |
| R424 | Methylation | Uniprot | |
| R436 | Methylation | Uniprot | |
| R445 | Methylation | Uniprot | |
| S449 | Phosphorylation | Uniprot |
研究背景
Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.
Binds and promotes bundling of vimentin filaments originating from the Golgi.
Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome>Centriole. Golgi apparatus.
Note: More abundantly located around the mother centriole.
Homooctamer, including four polyglutamate binding sites. The subunits are arranged as a tetramer of dimers, and form a planar ring-shaped structure (By similarity).
In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family.
In the N-terminal section; belongs to the formiminotransferase family.
研究領域
· Metabolism > Amino acid metabolism > Histidine metabolism.
· Metabolism > Metabolism of cofactors and vitamins > One carbon pool by folate.
· Metabolism > Global and overview maps > Metabolic pathways.
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