HTATSF1 Antibody - #DF13078
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF13078, RRID:AB_2846038.
折りたたみ／展開
Cofactor required for Tat activation of HIV 1 transcription; dJ196E23.2; HIV Tat specific factor 1; HTATSF1; HTSF-1; HTSF1; TAT SF1; Tat-SF1;
免疫原
- O43719 HTSF1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSGTNLDGNDEFDEQLRMQELYGDGKDGDTQTDAGGEPDSLGQQPTDTPYEWDLDKKAWFPKITEDFIATYQANYGFSNDGASSSTANVEDVHARTAEEPPQEKAPEPTDARKKGEKRKAESGWFHVEEDRNTNVYVSGLPPDITVDEFIQLMSKFGIIMRDPQTEEFKVKLYKDNQGNLKGDGLCCYLKRESVELALKLLDEDEIRGYKLHVEVAKFQLKGEYDASKKKKKCKDYKKKLSMQQKQLDWRPERRAGPSRMRHERVVIIKNMFHPMDFEDDPLVLNEIREDLRVECSKFGQIRKLLLFDRHPDGVASVSFRDPEEADYCIQTLDGRWFGGRQITAQAWDGTTDYQVEETSREREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDERGTLGGFGSVEEGPLSTGSSFILSSDDDDDDI
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O43719 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| S2 | Phosphorylation | Uniprot | |
| T4 | Phosphorylation | Uniprot | |
| R17 | Methylation | Uniprot | |
| Y22 | Phosphorylation | Uniprot | |
| T30 | Phosphorylation | Uniprot | |
| T32 | Phosphorylation | Uniprot | |
| S40 | Phosphorylation | Uniprot | |
| T48 | Phosphorylation | Uniprot | |
| Y50 | Phosphorylation | Uniprot | |
| K56 | Ubiquitination | Uniprot | |
| Y71 | Phosphorylation | Uniprot | |
| Y75 | Phosphorylation | Uniprot | |
| S78 | Phosphorylation | Uniprot | |
| K104 | Ubiquitination | Uniprot | |
| K119 | Ubiquitination | Uniprot | |
| S122 | Phosphorylation | Uniprot | |
| S154 | Phosphorylation | Uniprot | |
| K169 | Acetylation | Uniprot | |
| K169 | Ubiquitination | Uniprot | |
| K174 | Acetylation | Uniprot | |
| K174 | Ubiquitination | Uniprot | |
| K181 | Ubiquitination | Uniprot | |
| K190 | Ubiquitination | Uniprot | |
| K199 | Ubiquitination | Uniprot | |
| R207 | Methylation | Uniprot | |
| K210 | Ubiquitination | Uniprot | |
| K217 | Ubiquitination | Uniprot | |
| K221 | Sumoylation | Uniprot | |
| K221 | Ubiquitination | Uniprot | |
| Y224 | Phosphorylation | Uniprot | |
| K239 | Ubiquitination | Uniprot | |
| S241 | Phosphorylation | Uniprot | |
| K245 | Ubiquitination | Uniprot | |
| K297 | Ubiquitination | Uniprot | |
| K303 | Ubiquitination | Uniprot | |
| R309 | Methylation | Uniprot | |
| Y327 | Phosphorylation | Uniprot | |
| Y353 | Phosphorylation | Uniprot | |
| R367 | Methylation | Uniprot | |
| R380 | Methylation | Uniprot | |
| S385 | Phosphorylation | Uniprot | |
| S387 | Phosphorylation | Uniprot | |
| S391 | Phosphorylation | Uniprot | |
| R393 | Methylation | Uniprot | |
| R400 | Methylation | Uniprot | |
| S403 | Phosphorylation | Uniprot | |
| S407 | Phosphorylation | Uniprot | |
| T408 | Phosphorylation | Uniprot | |
| S409 | Phosphorylation | Uniprot | |
| T416 | Phosphorylation | Uniprot | |
| K429 | Sumoylation | Uniprot | |
| T434 | Phosphorylation | Uniprot | |
| S445 | Phosphorylation | Uniprot | |
| S452 | Phosphorylation | Uniprot | |
| S453 | Phosphorylation | Uniprot | |
| S467 | Phosphorylation | Uniprot | |
| K473 | Ubiquitination | Uniprot | |
| S479 | Phosphorylation | Uniprot | |
| S481 | Phosphorylation | Uniprot | |
| S485 | Phosphorylation | Uniprot | |
| S494 | Phosphorylation | Uniprot | |
| S498 | Phosphorylation | Uniprot | |
| K504 | Acetylation | Uniprot | |
| K505 | Acetylation | Uniprot | |
| K506 | Acetylation | Uniprot | |
| S521 | Phosphorylation | Uniprot | |
| S529 | Phosphorylation | Uniprot | |
| S539 | Phosphorylation | Uniprot | |
| S544 | Phosphorylation | Uniprot | |
| S557 | Phosphorylation | Uniprot | |
| S561 | Phosphorylation | Uniprot | |
| S579 | Phosphorylation | Uniprot | |
| S597 | Phosphorylation | Uniprot | |
| S600 | Phosphorylation | Uniprot | |
| S607 | Phosphorylation | Uniprot | |
| S616 | Phosphorylation | Uniprot | |
| S624 | Phosphorylation | Uniprot | |
| T633 | Phosphorylation | Uniprot | |
| Y634 | Phosphorylation | Uniprot | |
| S642 | Phosphorylation | Uniprot | |
| Y650 | Phosphorylation | Uniprot | |
| S676 | Phosphorylation | Uniprot | |
| S702 | Phosphorylation | Uniprot | |
| K705 | Ubiquitination | Uniprot | |
| S713 | Phosphorylation | Uniprot | |
| S714 | Phosphorylation | Uniprot | |
| K716 | Ubiquitination | Uniprot | |
| S721 | Phosphorylation | Uniprot | |
| S739 | Phosphorylation | Uniprot | |
| T740 | Phosphorylation | Uniprot | |
| S743 | Phosphorylation | Uniprot | |
| S747 | Phosphorylation | Uniprot | |
| S748 | Phosphorylation | Uniprot |
研究背景
Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus.
Nucleus.
Widely expressed.
Component of a complex which is at least composed of HTATSF1/Tat-SF1, the P-TEFb complex components CDK9 and CCNT1, RNA polymerase II, SUPT5H, and NCL/nucleolin. Interacts with GTF2F2/RAP30 and POLR2A. Interacts with TCERG1/CA150. Interacts with SF3A2/SAP62 and the spliceosomal U small nuclear ribonucleoproteins (snRNPs).
The RRM domains mediate interaction with U snRNPs.
Belongs to the HTATSF1 family.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.