製品: RCBTB1 Antibody
カタログ: AF0248
タンパク質の説明: Rabbit polyclonal antibody to RCBTB1
アプリケーション: WB IHC IF/ICC
反応性: Human, Mouse
予測: Pig, Bovine, Horse, Sheep, Rabbit, Dog
分子量: 58kDa; 58kD(Calculated).
ユニプロット: Q8NDN9
RRID: AB_2833423

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:3000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse
予測:
Pig(100%), Bovine(92%), Horse(100%), Sheep(92%), Rabbit(92%), Dog(100%)
クローナリティ:
Polyclonal
特異性:
RCBTB1 Antibody detects endogenous levels of total RCBTB1.
RRID:
AB_2833423
引用形式: Affinity Biosciences Cat# AF0248, RRID:AB_2833423.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

Chronic lymphocytic leukemia deletion region gene 7 protein; CLL deletion region gene 7 protein; CLLL7; CLLL7 protein; E4.5; GDP/GTP exchange factor (GEF) like protein; GLP; Guanine nucleotide exchange factor; Hypothetical protein FLJ39335; RCBT1_HUMAN; Rcbtb1; RCC1 and BTB domain-containing protein 1; Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1; Regulator of chromosome condensation and BTB domain-containing protein 1; RP11-185C18.1;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
発現特異性:
Q8NDN9 RCBT1_HUMAN:

Ubiquitously expressed (PubMed:11306461, PubMed:27486781). In the retina, present in the nerve fiber layer and to a lesser extent in the inner and outer plexiform layers (at protein level) (PubMed:27486781).

タンパク質の説明:
RCBTB1 May be involved in cell cycle regulation by chromatin remodeling. 2 isoforms of the human protein are produced by alternative splicing.
タンパク質配列:
MVDVGKWPIFTLLSPQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQCRGQSVILPHLTHFSCTDDVFACFATPAVSWRLLSVEHEDFLTVAESLKKEFDSPETADLKFRIDGKYIHVHKAVLKIRCEHFRSMFQSYWNEDMKEVIEIDQFSYPVYRAFLQYLYTDTVDLPPEDAIGLLDLATSYCENRLKKLCQHIIKRGITVENAFSLFSAAVRYDAEDLEEFCFKFCINHLTEVTQTAAFWQMDGPLLKEFIAKASKCGAFKN

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Dog
100
Bovine
92
Sheep
92
Rabbit
92
Xenopus
67
Zebrafish
67
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q8NDN9 基板として

Site PTM Type Enzyme
K67 Ubiquitination
K173 Ubiquitination
K283 Ubiquitination
K373 Ubiquitination
K379 Ubiquitination
K385 Ubiquitination
K464 Ubiquitination
K522 Ubiquitination
K525 Ubiquitination

研究背景

機能:

May be involved in cell cycle regulation by chromatin remodeling.

細胞の位置付け:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Ubiquitously expressed. In the retina, present in the nerve fiber layer and to a lesser extent in the inner and outer plexiform layers (at protein level).

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