IRF2BP2 Antibody - #DF13096
| 製品: | IRF2BP2 Antibody |
| カタログ: | DF13096 |
| タンパク質の説明: | Rabbit polyclonal antibody to IRF2BP2 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse |
| 予測: | Sheep, Dog, Chicken |
| 分子量: | 61 kDa; 61kD(Calculated). |
| ユニプロット: | Q7Z5L9 |
| RRID: | AB_2846056 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF13096, RRID:AB_2846056.
折りたたみ／展開
I2BP2_HUMAN; Interferon regulatory factor 2 binding protein 2; Interferon regulatory factor 2-binding protein 2; IRF-2-binding protein 2; IRF-2BP2; IRF2 binding protein 2; IRF2BP2;
免疫原
- Q7Z5L9 I2BP2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAAVAVAAASRRQSCYLCDLPRMPWAMIWDFTEPVCRGCVNYEGADRVEFVIETARQLKRAHGCFPEGRSPPGAAASAAAKPPPLSAKDILLQQQQQLGHGGPEAAPRAPQALERYPLAAAAERPPRLGSDFGSSRPAASLAQPPTPQPPPVNGILVPNGFSKLEEPPELNRQSPNPRRGHAVPPTLVPLMNGSATPLPTALGLGGRAAASLAAVSGTAAASLGSAQPTDLGAHKRPASVSSSAAVEHEQREAAAKEKQPPPPAHRGPADSLSTAAGAAELSAEGAGKSRGSGEQDWVNRPKTVRDTLLALHQHGHSGPFESKFKKEPALTAGRLLGFEANGANGSKAVARTARKRKPSPEPEGEVGPPKINGEAQPWLSTSTEGLKIPMTPTSSFVSPPPPTASPHSNRTTPPEAAQNGQSPMAALILVADNAGGSHASKDANQVHSTTRRNSNSPPSPSSMNQRRLGPREVGGQGAGNTGGLEPVHPASLPDSSLATSAPLCCTLCHERLEDTHFVQCPSVPSHKFCFPCSRQSIKQQGASGEVYCPSGEKCPLVGSNVPWAFMQGEIATILAGDVKVKKERDS
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q7Z5L9 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| S15 | Phosphorylation | Uniprot | |
| Y17 | Phosphorylation | Uniprot | |
| S71 | Phosphorylation | Uniprot | |
| S78 | Phosphorylation | Uniprot | |
| S87 | Phosphorylation | Uniprot | |
| R109 | Methylation | Uniprot | |
| R116 | Methylation | Uniprot | |
| R125 | Methylation | Uniprot | |
| S131 | Phosphorylation | Uniprot | |
| S141 | Phosphorylation | Uniprot | |
| T147 | Phosphorylation | Uniprot | |
| S175 | Phosphorylation | Uniprot | |
| T197 | Phosphorylation | Uniprot | |
| S240 | Phosphorylation | Uniprot | |
| S242 | Phosphorylation | Uniprot | |
| S243 | Phosphorylation | Uniprot | |
| S244 | Phosphorylation | Uniprot | |
| S283 | Phosphorylation | Uniprot | |
| K289 | Ubiquitination | Uniprot | |
| S290 | Phosphorylation | Uniprot | |
| R291 | Methylation | Uniprot | |
| S293 | Phosphorylation | Uniprot | |
| K303 | Ubiquitination | Uniprot | |
| S318 | Phosphorylation | Uniprot | |
| S323 | Phosphorylation | Uniprot | |
| K324 | Ubiquitination | Uniprot | |
| K327 | Ubiquitination | Uniprot | |
| S360 | Phosphorylation | Uniprot | |
| S381 | Phosphorylation | Uniprot | |
| S383 | Phosphorylation | Uniprot | |
| T392 | Phosphorylation | Uniprot | |
| S399 | Phosphorylation | Uniprot | |
| T404 | Phosphorylation | Uniprot | |
| S406 | Phosphorylation | Uniprot | |
| S409 | Phosphorylation | Uniprot | |
| T412 | Phosphorylation | Uniprot | |
| T413 | Phosphorylation | Uniprot | |
| S423 | Phosphorylation | Uniprot | |
| S455 | Phosphorylation | Uniprot | |
| S457 | Phosphorylation | Uniprot | |
| S460 | Phosphorylation | Uniprot | |
| S462 | Phosphorylation | Uniprot | |
| S463 | Phosphorylation | Uniprot | |
| S492 | Phosphorylation | Uniprot | |
| K539 | Ubiquitination | Uniprot |
研究背景
Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles. Plays a role in immature B-cell differentiation.
Phosphorylation at Ser-360 is required for nuclear targeting.
Cytoplasm. Nucleus.
Interacts with IRF2. Part of a corepressor complex containing IRF2 and IRF2BP1. Interacts with VGLL4.
The C-terminal RING-type zinc finger domain is sufficient for interaction with IRF2.
Belongs to the IRF2BP family.
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