LIFR Antibody - #DF13129
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF13129, RRID:AB_2846089.
折りたたみ／展開
CD118; CD118 antigen; FLJ98106; FLJ99923; Leukemia inhibitory factor receptor alpha; Leukemia inhibitory factor receptor; LIF R; LIF receptor; LIF-R; Lifr; LIFR_HUMAN; SJS2; STWS; SWS;
免疫原
- P42702 LIFR_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MMDIYVCLKRPSWMVDNKRMRTASNFQWLLSTFILLYLMNQVNSQKKGAPHDLKCVTNNLQVWNCSWKAPSGTGRGTDYEVCIENRSRSCYQLEKTSIKIPALSHGDYEITINSLHDFGSSTSKFTLNEQNVSLIPDTPEILNLSADFSTSTLYLKWNDRGSVFPHRSNVIWEIKVLRKESMELVKLVTHNTTLNGKDTLHHWSWASDMPLECAIHFVEIRCYIDNLHFSGLEEWSDWSPVKNISWIPDSQTKVFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIKIRNISVSASSGTNVVFTTEDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEAPTNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDKNDYIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKGILLTWHYDPNMTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAILIPVAVAVIVGVVTSILCYRKREWIKETFYPDIPNPENCKALQFQKSVCEGSSALKTLEMNPCTPNNVEVLETRSAFPKIEDTEIISPVAERPEDRSDAEPENHVVVSYCPPIIEEEIPNPAADEAGGTAQVIYIDVQSMYQPQAKPEEEQENDPVGGAGYKPQMHLPINSTVEDIAAEEDLDKTAGYRPQANVNTWNLVSPDSPRSIDSNSEIVSFGSPCSINSRQFLIPPKDEDSPKSNGGGWSFTNFFQNKPND
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P42702 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N131 | N-Glycosylation | Uniprot | |
| K179 | Ubiquitination | Uniprot | |
| K186 | Ubiquitination | Uniprot | |
| K253 | Ubiquitination | Uniprot | |
| N303 | N-Glycosylation | Uniprot | |
| Y369 | Phosphorylation | Uniprot | |
| Y379 | Phosphorylation | Uniprot | |
| N407 | N-Glycosylation | Uniprot | |
| N426 | N-Glycosylation | Uniprot | |
| S490 | Phosphorylation | Uniprot | |
| S491 | Phosphorylation | Uniprot | |
| Y492 | Phosphorylation | Uniprot | |
| K526 | Ubiquitination | Uniprot | |
| K610 | Acetylation | Uniprot | |
| S665 | Phosphorylation | Uniprot | |
| Y759 | Phosphorylation | Uniprot | |
| Y762 | Phosphorylation | Uniprot | |
| K804 | Ubiquitination | Uniprot | |
| Y807 | Phosphorylation | Uniprot | |
| S833 | Phosphorylation | Uniprot | |
| K866 | Ubiquitination | Uniprot | |
| K880 | Acetylation | Uniprot | |
| K880 | Ubiquitination | Uniprot | |
| K886 | Acetylation | Uniprot | |
| K886 | Ubiquitination | Uniprot | |
| S887 | Phosphorylation | Uniprot | |
| K896 | Acetylation | Uniprot | |
| T904 | Phosphorylation | Uniprot | |
| S927 | Phosphorylation | Uniprot | |
| Y974 | Phosphorylation | Uniprot | |
| S1041 | Phosphorylation | Uniprot | |
| S1044 | Phosphorylation | P28482 (MAPK1) , P27361 (MAPK3) | Uniprot |
| S1047 | Phosphorylation | Uniprot | |
| S1059 | Phosphorylation | Uniprot | |
| S1077 | Phosphorylation | Uniprot |
研究背景
Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.
Cell membrane>Single-pass type I membrane protein.
Secreted.
Heterodimer composed of LIFR and IL6ST. The heterodimer formed by LIFR and IL6ST interacts with the complex formed by CNTF and CNTFR.
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.
Belongs to the type I cytokine receptor family. Type 2 subfamily.
研究領域
· Cellular Processes > Cellular community - eukaryotes > Signaling pathways regulating pluripotency of stem cells. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction. (View pathway)
· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway. (View pathway)
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