Neogenin Antibody - #DF13183
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF13183, RRID:AB_2846143.
折りたたみ／展開
Immunoglobulin superfamily DCC subclass member 2; NEO1; NEO1_HUMAN; Neogenin; Ngn (gene name);
免疫原
- Q92859 NEO1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQASGSGGKGSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDTMPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSYEPDELTKEMAHLEGLMKDLNAITTA
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q92859 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T51 | Phosphorylation | Uniprot | |
| S68 | Phosphorylation | Uniprot | |
| S69 | Phosphorylation | Uniprot | |
| Y164 | Phosphorylation | Uniprot | |
| N210 | N-Glycosylation | Uniprot | |
| Y219 | Phosphorylation | Uniprot | |
| S225 | Phosphorylation | Uniprot | |
| N470 | N-Glycosylation | Uniprot | |
| N489 | N-Glycosylation | Uniprot | |
| Y602 | Phosphorylation | Uniprot | |
| T603 | Phosphorylation | Uniprot | |
| N639 | N-Glycosylation | Uniprot | |
| T955 | Phosphorylation | Uniprot | |
| S956 | Phosphorylation | Uniprot | |
| S1056 | Phosphorylation | Uniprot | |
| S1057 | Phosphorylation | Uniprot | |
| S1066 | Phosphorylation | Uniprot | |
| S1068 | Phosphorylation | Uniprot | |
| S1080 | Phosphorylation | Uniprot | |
| Y1082 | Phosphorylation | Uniprot | |
| K1173 | Ubiquitination | Uniprot | |
| S1178 | Phosphorylation | Uniprot | |
| T1188 | Phosphorylation | Uniprot | |
| S1194 | Phosphorylation | Uniprot | |
| T1198 | Phosphorylation | Uniprot | |
| S1203 | Phosphorylation | Uniprot | |
| S1214 | Phosphorylation | Uniprot | |
| S1220 | Phosphorylation | Uniprot | |
| Y1279 | Phosphorylation | Uniprot | |
| T1289 | Phosphorylation | Uniprot | |
| S1292 | Phosphorylation | Uniprot | |
| S1294 | Phosphorylation | Uniprot | |
| S1299 | Phosphorylation | Uniprot | |
| T1300 | Phosphorylation | Uniprot | |
| S1302 | Phosphorylation | Uniprot | |
| T1382 | Phosphorylation | Uniprot | |
| S1386 | Phosphorylation | Uniprot | |
| S1401 | Phosphorylation | Uniprot | |
| T1404 | Phosphorylation | Uniprot | |
| S1432 | Phosphorylation | Uniprot | |
| S1434 | Phosphorylation | Uniprot | |
| S1435 | Phosphorylation | Uniprot | |
| Y1436 | Phosphorylation | Uniprot |
研究背景
Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response.
Cell membrane>Single-pass type I membrane protein.
Widely expressed and also in cancer cell lines.
Interacts with MYO10 (By similarity). Interacts with RGMA and RGMB. Interacts with BMP2, BMP4, BMP6, and BMP7.
The Fibronectin repeats 5 and 6 mediate interaction with RGM family molecules.
Belongs to the immunoglobulin superfamily. DCC family.
研究領域
· Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs). (View pathway)
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