NUS1 Antibody - #DF13200
| 製品: | NUS1 Antibody |
| カタログ: | DF13200 |
| タンパク質の説明: | Rabbit polyclonal antibody to NUS1 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Horse, Sheep, Rabbit, Dog |
| 分子量: | 31 kDa; 33kD(Calculated). |
| ユニプロット: | Q96E22 |
| RRID: | AB_2846160 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF13200, RRID:AB_2846160.
免疫原
- Q96E22 NGBR_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTGLYELVWRVLHALLCLHRTLTSWLRVRFGTWNWIWRRCCRAASAAVLAPLGFTLRKPPAVGRNRRHHRHPRGGSCLAAAHHRMRWRADGRSLEKLPVHMGLVITEVEQEPSFSDIASLVVWCMAVGISYISVYDHQGIFKRNNSRLMDEILKQQQELLGLDCSKYSPEFANSNDKDDQVLNCHLAVKVLSPEDGKADIVRAAQDFCQLVAQKQKRPTDLDVDTLASLLSSNGCPDPDLVLKFGPVDSTLGFLPWHIRLTEIVSLPSHLNISYEDFFSALRQYAACEQRLGK
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q96E22 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S45 | Phosphorylation | Uniprot | |
| S76 | Phosphorylation | Uniprot | |
| N144 | N-Glycosylation | Uniprot | |
| K154 | Ubiquitination | Uniprot | |
| K166 | Ubiquitination | Uniprot | |
| S168 | Phosphorylation | Uniprot | |
| K177 | Ubiquitination | Uniprot | |
| K189 | Ubiquitination | Uniprot | |
| K197 | Ubiquitination | Uniprot | |
| K214 | Ubiquitination | Uniprot | |
| N271 | N-Glycosylation | Uniprot |
研究背景
With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator.
Endoplasmic reticulum membrane>Multi-pass membrane protein.
Note: Colocalizes with Nogo-B during VEGF and wound healing angiogenesis.
Forms an active dehydrodolichyl diphosphate synthase complex with DHDDS. Interacts with NPC2.
Belongs to the UPP synthase family.
研究領域
· Metabolism > Metabolism of terpenoids and polyketides > Terpenoid backbone biosynthesis.
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