NXF2 Antibody - #DF13201
| 製品: | NXF2 Antibody |
| カタログ: | DF13201 |
| タンパク質の説明: | Rabbit polyclonal antibody to NXF2 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 分子量: | 72 kDa; 72kD(Calculated). |
| ユニプロット: | Q9GZY0 |
| RRID: | AB_2846161 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF13201, RRID:AB_2846161.
折りたたみ／展開
cancer/testis antigen 39; CT39; FLJ20416; Nuclear RNA export factor 2; NXF2B; T complex protein 11 homolog; TAP like protein 2; TAPL-2; TAPL2; TCP11X2;
免疫原
- Q9GZY0 NXF2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MCSTLKKCGTYRTEVAECHDHGSTFQGRKKGGSSFRDNFDKRSCHYEHGGYERPPSHCQENDGSVEMRDVHKDQQLRHTPYSIRCERRMKWHSEDEIRITTWRNRKPPERKMSQNTQDGYTRNWFKVTIPYGIKYDKAWLMNSIQSHCSDRFTPVDFHYVRNRACFFVQDASAASALKDVSYKIYDDENQKICIFVNHSTAPYSVKNKLKPGQMEMLKLTMNKRYNVSQQALDLQNLRFDPDLMGRDIDIILNRRNCMAATLKIIERNFPELLSLNLCNNKLYQLDGLSDITEKAPKVKTLNLSKNKLESAWELGKVKGLKLEELWLEGNPLCSTFSDQSAYVSAIRDCFPKLLRLDGRELSAPVIVDIDSSETMKPCKENFTGSETLKHLVLQFLQQYYSIYDSGDRQGLLGAYHDEACFSLAIPFDPKDSAPSSLCKYFEDSRNMKTLKDPYLKGELLRRTKRDIVDSLSALPKTQHDLSSILVDVWCQTERMLCFSVNGVFKEVEGQSQGSVLAFTRTFIATPGSSSSLCIVNDELFVRDASPQETQSAFSIPVSTLSSSSEPSLSQEQQEMVQAFSAQSGMKLEWSQKCLQDNEWNYTRAGQAFTMLQTEGKIPAEAFKQIS
PTMs - Q9GZY0 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T13 | Phosphorylation | Uniprot | |
| S34 | Phosphorylation | Uniprot | |
| S82 | Phosphorylation | Uniprot | |
| K90 | Methylation | Uniprot | |
| Y120 | Phosphorylation | Uniprot | |
| Y185 | Phosphorylation | Uniprot | |
| Y203 | Phosphorylation | Uniprot | |
| T383 | Phosphorylation | Uniprot |
研究背景
Involved in the export of mRNA from the nucleus to the cytoplasm.
Nucleus>Nucleoplasm. Cytoplasm.
Note: Localized in the nucleoplasm and at the nuclear envelope. Shuttles between the nucleus and the cytoplasm.
Expressed almost exclusively in testis. Also expressed in several cancers.
Interacts with NXT1, NXT2, E1B-AP5, the REF proteins and with nucleoporins, Nup62, Nup153 and Nup214. Interacts with LUZP4.
The NTF2 domain heterodimerizes with NXT1 and NXT2. The formation of NXF1/NXT1 heterodimers is required for NXF2-mediated nuclear mRNA export.
The leucine-rich repeats and the NTF2-domain are essential for the export of mRNA from the nucleus.
The C-terminal fragment, containing the TAP domain (also called UBA-like domain) and part of the NTF2-like domain, named the NPC-binding domain, mediates direct interactions with nucleoporin-FG-repeats and is necessary and sufficient for localization of NXF2 to the nuclear rim.
The RNA-binding domain is a non-canonical RNP-type domain.
Belongs to the NXF family.
研究領域
· Genetic Information Processing > Translation > Ribosome biogenesis in eukaryotes.
· Genetic Information Processing > Translation > RNA transport.
· Genetic Information Processing > Translation > mRNA surveillance pathway.
· Human Diseases > Infectious diseases: Viral > Influenza A.
· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.
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