Prealbumin antibody - #BF0713
| 製品: | Prealbumin antibody |
| カタログ: | BF0713 |
| タンパク質の説明: | Mouse monoclonal antibody to Prealbumin |
| アプリケーション: | WB IHC |
| 反応性: | Human |
| 分子量: | 16 kDa; 16kD(Calculated). |
| ユニプロット: | P02766 |
| RRID: | AB_2846204 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# BF0713, RRID:AB_2846204.
折りたたみ／展開
Amyloid;Amyloidosis I;ATTR;Carpal tunnel syndrome 1;CTS;Prealbumin;Transthyretin;Prealbumin;TTR
免疫原
A synthetic peptide
Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver.
- P02766 TTHY_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
PTMs - P02766 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| C10 | S-Nitrosylation | Uniprot | |
| T23 | Phosphorylation | Uniprot | |
| T25 | Phosphorylation | Uniprot | |
| S72 | Phosphorylation | Uniprot | |
| N118 | N-Glycosylation | Uniprot | |
| Y125 | Phosphorylation | Uniprot | |
| S137 | Phosphorylation | Uniprot | |
| T138 | Phosphorylation | Uniprot |
研究背景
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
Not glycosylated under normal conditions. Following unfolding, caused for example by variant AMYL-TTR 'Gly-38', the cryptic Asn-118 site is exposed and glycosylated by STT3B-containing OST complex, leading to its degradation by the ER-associated degradation (ERAD) pathway.
Secreted. Cytoplasm.
Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver.
Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4.
Each monomer has two 4-stranded beta sheets and the shape of a prolate ellipsoid. Antiparallel beta-sheet interactions link monomers into dimers. A short loop from each monomer forms the main dimer-dimer interaction. These two pairs of loops separate the opposed, convex beta-sheets of the dimers to form an internal channel.
Belongs to the transthyretin family.
研究領域
· Organismal Systems > Endocrine system > Thyroid hormone synthesis.
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