KCNN3 Antibody - #DF13233
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF13233, RRID:AB_2846252.
折りたたみ／展開
hSK3; KCa2.3; Kcnn3; KCNN3_HUMAN; Potassium calcium activated channel subfamily N member 3; Potassium channel calcium activated intermediate/small conductance subfamily N alpha member 3; Potassium channel, calcium activated, intermediate/small conductance, subfamily N, member 3; Potassium intermediate/small conductance calcium activated channel subfamily N member 3; SK3; SKCa 3; SKCa3; Small conductance calcium-activated potassium channel protein 3;
免疫原
- Q9UGI6 KCNN3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQQQQQQQPPPPAPPAAPQQPLGPSLQPQPPQLQQQQQQQQQQQQQQPPHPLSQLAQLQSQPVHPGLLHSSPTAFRAPPSSNSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIEAETEGQPLQLFSPSNPPEIVISSREDNHAHQTLLHHPNATHNHQHAGTTASSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLSAIIEARGVSVAVGTTHTPISDSPIGVSSTSFPTPYTSSSSC
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9UGI6 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S159 | Phosphorylation | Uniprot | |
| S167 | Phosphorylation | Uniprot | |
| T171 | Phosphorylation | Uniprot | |
| Y180 | Phosphorylation | Uniprot | |
| S189 | Phosphorylation | Uniprot | |
| S408 | Phosphorylation | Uniprot | |
| K442 | Ubiquitination | Uniprot | |
| K550 | Ubiquitination | Uniprot | |
| K569 | Ubiquitination | Uniprot | |
| K615 | Sumoylation | Uniprot | |
| K620 | Ubiquitination | Uniprot | |
| K654 | Ubiquitination | Uniprot |
研究背景
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
Membrane>Multi-pass membrane protein.
Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity).
Belongs to the potassium channel KCNN family. KCa2.3/KCNN3 subfamily.
研究領域
· Organismal Systems > Endocrine system > Insulin secretion. (View pathway)
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