SA1 Antibody - #DF13245
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF13245, RRID:AB_2846264.
折りたたみ／展開
Cohesin subunit SA 1; Cohesin subunit SA-1; Cohesin Subunit SA1; Nuclear protein stromal antigen 1; SA 1; SCC 3 homolog 1; Scc3; SCC3 homolog 1; STAG 1; stag1; STAG1_HUMAN; Stromal antigen 1;
免疫原
- Q8WVM7 STAG1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MITSELPVLQDSTNETTAHSDAGSELEETEVKGKRKRGRPGRPPSTNKKPRKSPGEKSRIEAGIRGAGRGRANGHPQQNGEGEPVTLFEVVKLGKSAMQSVVDDWIESYKQDRDIALLDLINFFIQCSGCRGTVRIEMFRNMQNAEIIRKMTEEFDEDSGDYPLTMPGPQWKKFRSNFCEFIGVLIRQCQYSIIYDEYMMDTVISLLTGLSDSQVRAFRHTSTLAAMKLMTALVNVALNLSIHQDNTQRQYEAERNKMIGKRANERLELLLQKRKELQENQDEIENMMNSIFKGIFVHRYRDAIAEIRAICIEEIGVWMKMYSDAFLNDSYLKYVGWTLHDRQGEVRLKCLKALQSLYTNRELFPKLELFTNRFKDRIVSMTLDKEYDVAVEAIRLVTLILHGSEEALSNEDCENVYHLVYSAHRPVAVAAGEFLHKKLFSRHDPQAEEALAKRRGRNSPNGNLIRMLVLFFLESELHEHAAYLVDSLWESSQELLKDWECMTELLLEEPVQGEEAMSDRQESALIELMVCTIRQAAEAHPPVGRGTGKRVLTAKERKTQIDDRNKLTEHFIITLPMLLSKYSADAEKVANLLQIPQYFDLEIYSTGRMEKHLDALLKQIKFVVEKHVESDVLEACSKTYSILCSEEYTIQNRVDIARSQLIDEFVDRFNHSVEDLLQEGEEADDDDIYNVLSTLKRLTSFHNAHDLTKWDLFGNCYRLLKTGIEHGAMPEQIVVQALQCSHYSILWQLVKITDGSPSKEDLLVLRKTVKSFLAVCQQCLSNVNTPVKEQAFMLLCDLLMIFSHQLMTGGREGLQPLVFNPDTGLQSELLSFVMDHVFIDQDEENQSMEGDEEDEANKIEALHKRRNLLAAFSKLIIYDIVDMHAAADIFKHYMKYYNDYGDIIKETLSKTRQIDKIQCAKTLILSLQQLFNELVQEQGPNLDRTSAHVSGIKELARRFALTFGLDQIKTREAVATLHKDGIEFAFKYQNQKGQEYPPPNLAFLEVLSEFSSKLLRQDKKTVHSYLEKFLTEQMMERREDVWLPLISYRNSLVTGGEDDRMSVNSGSSSSKTSSVRNKKGRPPLHKKRVEDESLDNTWLNRTDTMIQTPGPLPAPQLTSTVLRENSRPMGDQIQEPESEHGSEPDFLHNPQMQISWLGQPKLEDLNRKDRTGMNYMKVRTGVRHAVRGLMEEDAEPIFEDVMMSSRSQLEDMNEEFEDTMVIDLPPSRNRRERAELRPDFFDSAAIIEDDSGFGMPMF
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8WVM7 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T17 | Phosphorylation | Uniprot | |
| S20 | Phosphorylation | Uniprot | |
| S24 | Phosphorylation | Uniprot | |
| T46 | Phosphorylation | Uniprot | |
| R65 | Methylation | Uniprot | |
| T152 | Phosphorylation | Uniprot | |
| S159 | Phosphorylation | Uniprot | |
| Y162 | Phosphorylation | Uniprot | |
| T165 | Phosphorylation | Uniprot | |
| K273 | Ubiquitination | Uniprot | |
| K333 | Methylation | Uniprot | |
| K366 | Ubiquitination | Uniprot | |
| K453 | Ubiquitination | Uniprot | |
| T568 | Phosphorylation | Uniprot | |
| T574 | Phosphorylation | Uniprot | |
| K618 | Methylation | Uniprot | |
| K621 | Acetylation | Uniprot | |
| Y689 | Phosphorylation | Uniprot | |
| T694 | Phosphorylation | Uniprot | |
| S756 | Phosphorylation | Uniprot | |
| S758 | Phosphorylation | Uniprot | |
| K759 | Ubiquitination | Uniprot | |
| S781 | Phosphorylation | Uniprot | |
| S847 | Phosphorylation | Uniprot | |
| K864 | Ubiquitination | Uniprot | |
| Y893 | Phosphorylation | Uniprot | |
| Y896 | Phosphorylation | Uniprot | |
| Y897 | Phosphorylation | Uniprot | |
| Y900 | Phosphorylation | Uniprot | |
| K905 | Acetylation | Uniprot | |
| K905 | Ubiquitination | Uniprot | |
| K916 | Ubiquitination | Uniprot | |
| T962 | Phosphorylation | Uniprot | |
| Y1025 | Phosphorylation | Uniprot | |
| S1051 | Phosphorylation | Uniprot | |
| T1054 | Phosphorylation | Uniprot | |
| S1062 | Phosphorylation | Uniprot | |
| S1065 | Phosphorylation | Uniprot | |
| S1067 | Phosphorylation | Uniprot | |
| S1068 | Phosphorylation | Uniprot | |
| S1070 | Phosphorylation | Uniprot | |
| S1093 | Phosphorylation | Uniprot | |
| T1108 | Phosphorylation | Uniprot | |
| S1126 | Phosphorylation | Uniprot | |
| S1138 | Phosphorylation | Uniprot | |
| S1142 | Phosphorylation | Uniprot | |
| T1171 | Phosphorylation | Uniprot | |
| S1251 | Phosphorylation | Uniprot |
研究背景
Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
Phosphorylated by PLK1. The large dissociation of cohesin from chromosome arms during prophase is partly due to its phosphorylation (By similarity).
Nucleus. Chromosome. Chromosome>Centromere.
Note: Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation.
Cohesin complexes are composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein (STAG1, STAG2 or STAG3). In cohesin complexes, STAG1 is mutually exclusive with STAG2 and STAG3. Interacts directly with RAD21 in cohesin complex (By similarity). Found in a cohesin complex with SMC1A, SMC3 and RAD21.
Belongs to the SCC3 family.
研究領域
· Cellular Processes > Cell growth and death > Cell cycle. (View pathway)
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.