Mineralocorticoid Receptor Antibody - #DF13302
| 製品: | Mineralocorticoid Receptor Antibody |
| カタログ: | DF13302 |
| タンパク質の説明: | Rabbit polyclonal antibody to Mineralocorticoid Receptor |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Zebrafish, Bovine, Horse, Rabbit, Dog |
| 分子量: | 107kDa; 107kD(Calculated). |
| ユニプロット: | P08235 |
| RRID: | AB_2846321 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF13302, RRID:AB_2846321.
折りたたみ／展開
Aldosterone receptor; MCR; MCR_HUMAN; MGC133092; Mineralocorticoid receptor; MLR; MR; NR3 C2; NR3C2; NR3C2 protein; Nuclear receptor subfamily 3 group C member 2;
免疫原
Ubiquitous. Highly expressed in distal tubules, convoluted tubules and cortical collecting duct in kidney, and in sweat glands. Detected at lower levels in cardiomyocytes, in epidermis and in colon enterocytes.
- P08235 MCR_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
METKGYHSLPEGLDMERRWGQVSQAVERSSLGPTERTDENNYMEIVNVSCVSGAIPNNSTQGSSKEKQELLPCLQQDNNRPGILTSDIKTELESKELSATVAESMGLYMDSVRDADYSYEQQNQQGSMSPAKIYQNVEQLVKFYKGNGHRPSTLSCVNTPLRSFMSDSGSSVNGGVMRAVVKSPIMCHEKSPSVCSPLNMTSSVCSPAGINSVSSTTASFGSFPVHSPITQGTPLTCSPNVENRGSRSHSPAHASNVGSPLSSPLSSMKSSISSPPSHCSVKSPVSSPNNVTLRSSVSSPANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPVNNAFSYTASGTSAGSSTLRDVVPSPDTQEKGAQEVPFPKTEEVESAISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNSKINSDSSFSVPIKQESTKHSCSGTSFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGFDGNCEGSGFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSARDQSFQHLSSFPPVNTLVESWKSHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPSKICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRLQKCLQAGMNLGARKSKKLGKLKGIHEEQPQQQQPPPPPPPPQSPEEGTTYIAPAKEPSVNTALVPQLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYIKELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAMLVEIISDQLPKVESGNAKPLYFHRK
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P08235 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T3 | Phosphorylation | Uniprot | |
| Y6 | Phosphorylation | Uniprot | |
| S8 | Phosphorylation | Uniprot | |
| S23 | Phosphorylation | Uniprot | |
| K89 | Sumoylation | Uniprot | |
| S111 | Phosphorylation | Uniprot | |
| S129 | Phosphorylation | Uniprot | |
| T159 | Phosphorylation | Uniprot | |
| S168 | Phosphorylation | Uniprot | |
| S183 | Phosphorylation | Uniprot | |
| S196 | Phosphorylation | Uniprot | |
| S227 | Phosphorylation | Uniprot | |
| S238 | Phosphorylation | Uniprot | |
| S248 | Phosphorylation | Uniprot | |
| S250 | Phosphorylation | Uniprot | |
| S255 | Phosphorylation | Uniprot | |
| S259 | Phosphorylation | Uniprot | |
| S262 | Phosphorylation | Uniprot | |
| S263 | Phosphorylation | Uniprot | |
| S274 | Phosphorylation | Uniprot | |
| S283 | Phosphorylation | Uniprot | |
| S287 | Phosphorylation | Uniprot | |
| S299 | Phosphorylation | Uniprot | |
| S311 | Phosphorylation | Uniprot | |
| S361 | Phosphorylation | Uniprot | |
| K399 | Sumoylation | Uniprot | |
| S424 | Phosphorylation | Uniprot | |
| K428 | Sumoylation | Uniprot | |
| S459 | Phosphorylation | Uniprot | |
| K464 | Acetylation | Uniprot | |
| K494 | Sumoylation | Uniprot | |
| T532 | Phosphorylation | Uniprot | |
| S543 | Phosphorylation | Uniprot | |
| K680 | Ubiquitination | Uniprot | |
| S703 | Phosphorylation | Uniprot | |
| T735 | Phosphorylation | Uniprot | |
| S737 | Phosphorylation | Uniprot | |
| T761 | Phosphorylation | Uniprot | |
| S843 | Phosphorylation | Uniprot | |
| K953 | Sumoylation | Uniprot | |
| K970 | Ubiquitination | Uniprot | |
| K977 | Ubiquitination | Uniprot |
研究背景
Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.
Phosphorylated.
Cytoplasm. Nucleus. Endoplasmic reticulum membrane>Peripheral membrane protein.
Note: Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane.
Ubiquitous. Highly expressed in distal tubules, convoluted tubules and cortical collecting duct in kidney, and in sweat glands. Detected at lower levels in cardiomyocytes, in epidermis and in colon enterocytes.
Heteromultimeric cytoplasmic complex with HSP90, HSP70, and FKBP4, in the absence of ligand. After ligand binding, it translocates to the nucleus and binds to DNA as a homodimer and as a heterodimer with NR3C1. May interact with HSD11B2 in the absence of ligand. Binds the coactivators NCOA1, NCOA2, TIF1 and NRIP1.
Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Belongs to the nuclear hormone receptor family. NR3 subfamily.
研究領域
· Organismal Systems > Excretory system > Aldosterone-regulated sodium reabsorption.
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