KAT8 Antibody - #DF13309
(2)
(2)
| 製品: | KAT8 Antibody |
| カタログ: | DF13309 |
| タンパク質の説明: | Rabbit polyclonal antibody to KAT8 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 52kDa; 52kD(Calculated). |
| ユニプロット: | Q9H7Z6 |
| RRID: | AB_2846328 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF13309, RRID:AB_2846328.
折りたたみ／展開
Histone acetyltransferase KAT8; Histone acetyltransferase MYST1; hMOF; K(lysine) acetyltransferase 8; KAT 8; Lysine acetyltransferase 8; MOF; MOZ; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1; MYST 1; MYST histone acetyltransferase 1; myst protein 1; MYST-1; MYST1; MYST1_HUMAN; Ortholog of Drosophila males absent on the first (MOF); Probable histone acetyltransferase MYST1; SAS2 and TIP60 protein 1; SAS2; SAS3; TIP60 protein 1; YBF2; YBF2/SAS3; ZC2HC8;
免疫原
- Q9H7Z6 KAT8_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAQGAAAAVAAGTSGVAGEGEPGPGENAAAEGTAPSPGRVSPPTPARGEPEVTVEIGETYLCRRPDSTWHSAEVIQSRVNDQEGREEFYVHYVGFNRRLDEWVDKNRLALTKTVKDAVQKNSEKYLSELAEQPERKITRNQKRKHDEINHVQKTYAEMDPTTAALEKEHEAITKVKYVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMKYEKSYRFHLGQCQWRQPPGKEIYRKSNISVYEVDGKDHKIYCQNLCLLAKLFLDHKTLYFDVEPFVFYILTEVDRQGAHIVGYFSKEKESPDGNNVACILTLPPYQRRGYGKFLIAFSYELSKLESTVGSPEKPLSDLGKLSYRSYWSWVLLEILRDFRGTLSIKDLSQMTSITQNDIISTLQSLNMVKYWKGQHVICVTPKLVEEHLKSAQYKKPPITVDSVCLKWAPPKHKQVKLSKK
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9H7Z6 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| T14 | Phosphorylation | Uniprot | |
| S15 | Phosphorylation | Uniprot | |
| S37 | Phosphorylation | Uniprot | |
| S42 | Phosphorylation | Uniprot | |
| Y90 | Phosphorylation | Uniprot | |
| K106 | Ubiquitination | Uniprot | |
| K113 | Acetylation | Uniprot | |
| K113 | Ubiquitination | Uniprot | |
| T114 | Phosphorylation | Uniprot | |
| K116 | Acetylation | Uniprot | |
| K125 | Ubiquitination | Uniprot | |
| K154 | Ubiquitination | Uniprot | |
| K168 | Acetylation | Uniprot | |
| K168 | Ubiquitination | Uniprot | |
| T174 | Phosphorylation | Uniprot | |
| K175 | Ubiquitination | Uniprot | |
| K177 | Acetylation | Uniprot | |
| K238 | Acetylation | Uniprot | |
| Y241 | Phosphorylation | Uniprot | |
| K243 | Ubiquitination | Uniprot | |
| K254 | Ubiquitination | Uniprot | |
| K257 | Ubiquitination | Uniprot | |
| K274 | Acetylation | Q9H7Z6 (KAT8) | Uniprot |
| S344 | Phosphorylation | Uniprot | |
| S348 | Phosphorylation | Uniprot | |
| K351 | Acetylation | Uniprot | |
| K351 | Ubiquitination | Uniprot | |
| T392 | Phosphorylation | Uniprot | |
| K410 | Ubiquitination | Uniprot | |
| K427 | Ubiquitination | Uniprot | |
| K433 | Ubiquitination | Uniprot | |
| K444 | Ubiquitination | Uniprot |
研究背景
Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Can also acetylate TP53/p53 at 'Lys-120'.
Autoacetylation at Lys-274 is required for binding histone H4 with high affinity and for proper function.
Nucleus. Chromosome.
Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the MOF/KAT8, MSL1/hampin, MSL2L1 and MSL3L1. Interacts with MSL1; the interaction is direct. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MOF/KAT8, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with the chromodomain of MORF4L1/MRG15. Interacts with ATM through the chromodomain. Interacts with KANSL1; the interaction is direct. Interacts with MSL3. Interacts with NELFD (By similarity).
Belongs to the MYST (SAS/MOZ) family.
参考文献
Application: WB Species: mouse Sample: colonic
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