Calcium Pump PMCA4 ATPase Antibody - #DF13326
(1)
(4)
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF13326, RRID:AB_2846345.
折りたたみ／展開
AT2B4_HUMAN; ATP2B2; Atp2b4; ATPase Ca++ transporting plasma membrane 4; Cation transporting ATPase; DKFZp686G08106; DKFZp686M088; Matrix remodelling associated 1; Matrix remodelling associated protein 1; Matrix-remodeling-associated protein 1; MXRA 1; MXRA1; OTTHUMP00000034088; OTTHUMP00000034089; Plasma membrane calcium ATPase 4; Plasma membrane calcium ATPase isoform 4; Plasma membrane calcium pump isoform 4; Plasma membrane calcium transporting ATPase 4; Plasma membrane calcium-transporting ATPase 4; PMCA 4; PMCA4; PMCA4b; PMCA4x; Sarcolemmal calcium pump;
免疫原
Isoform XB is the most abundant isoform and is expressed ubiquitously. Isoforms containing segment Z have only been detected in heart, while isoforms containing segment a have been found in heart, stomach and brain cortex.
- P23634 AT2B4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTNPSDRVLPANSMAESREGDFGCTVMELRKLMELRSRDALTQINVHYGGVQNLCSRLKTSPVEGLSGNPADLEKRRQVFGHNVIPPKKPKTFLELVWEALQDVTLIILEIAAIISLVLSFYRPAGEENELCGQVATTPEDENEAQAGWIEGAAILFSVIIVVLVTAFNDWSKEKQFRGLQCRIEQEQKFSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIILTLLGVNEDDEGEKKKKGKKQGVPENRNKAKTQDGVALEIQPLNSQEGIDNEEKDKKAVKVPKKEKSVLQGKLTRLAVQIGKAGLLMSALTVFILILYFVIDNFVINRRPWLPECTPIYIQYFVKFFIIGITVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYIGGIHYRQIPSPDVFLPKVLDLIVNGISINSAYTSKILPPEKEGGLPRQVGNKTECALLGFVTDLKQDYQAVRNEVPEEKLYKVYTFNSVRKSMSTVIRNPNGGFRMYSKGASEIILRKCNRILDRKGEAVPFKNKDRDDMVRTVIEPMACDGLRTICIAYRDFDDTEPSWDNENEILTELTCIAVVGIEDPVRPEVPDAIAKCKQAGITVRMVTGDNINTARAIATKCGILTPGDDFLCLEGKEFNRLIRNEKGEVEQEKLDKIWPKLRVLARSSPTDKHTLVKGIIDSTVGEHRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLKRRPYGRNKPLISRTMMKNILGHAFYQLIVIFILVFAGEKFFDIDSGRKAPLHSPPSQHYTIVFNTFVLMQLFNEINSRKIHGEKNVFSGIYRNIIFCSVVLGTFICQIFIVEFGGKPFSCTSLSLSQWLWCLFIGIGELLWGQFISAIPTRSLKFLKEAGHGTTKEEITKDAEGLDEIDHAEMELRRGQILWFRGLNRIQTQIDVINTFQTGASFKGVLRRQNMGQHLDVKLVPSSSYIKVVKAFHSSLHESIQKPYNQKSIHSFMTHPEFAIEEELPRTPLLDEEEEENPDKASKFGTRVLLLDGEVTPYANTNNNAVDCNQVQLPQSDSSLQSLETSV
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P23634 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S13 | Phosphorylation | Uniprot | |
| S17 | Phosphorylation | Uniprot | |
| K31 | Ubiquitination | Uniprot | |
| K59 | Ubiquitination | Uniprot | |
| S67 | Phosphorylation | Uniprot | |
| K75 | Ubiquitination | Uniprot | |
| K189 | Ubiquitination | Uniprot | |
| Y216 | Phosphorylation | Uniprot | |
| K233 | Ubiquitination | Uniprot | |
| S238 | Phosphorylation | Uniprot | |
| K247 | Ubiquitination | Uniprot | |
| K252 | Ubiquitination | Uniprot | |
| K314 | Ubiquitination | Uniprot | |
| S328 | Phosphorylation | Uniprot | |
| K337 | Ubiquitination | Uniprot | |
| K349 | Ubiquitination | Uniprot | |
| K355 | Ubiquitination | Uniprot | |
| T415 | Phosphorylation | Uniprot | |
| Y435 | Phosphorylation | Uniprot | |
| S436 | Phosphorylation | Uniprot | |
| K442 | Ubiquitination | Uniprot | |
| S464 | Phosphorylation | Uniprot | |
| K523 | Ubiquitination | Uniprot | |
| C537 | S-Nitrosylation | Uniprot | |
| K547 | Ubiquitination | Uniprot | |
| K561 | Ubiquitination | Uniprot | |
| K564 | Ubiquitination | Uniprot | |
| S570 | Phosphorylation | Uniprot | |
| R572 | Methylation | Uniprot | |
| S576 | Phosphorylation | Uniprot | |
| T577 | Phosphorylation | Uniprot | |
| K608 | Ubiquitination | Uniprot | |
| K615 | Ubiquitination | Uniprot | |
| C632 | S-Nitrosylation | Uniprot | |
| K686 | Ubiquitination | Uniprot | |
| T691 | Phosphorylation | Uniprot | |
| K709 | Ubiquitination | Uniprot | |
| K725 | Ubiquitination | Uniprot | |
| K735 | Ubiquitination | Uniprot | |
| K742 | Ubiquitination | Uniprot | |
| K745 | Ubiquitination | Uniprot | |
| S757 | Phosphorylation | Uniprot | |
| T759 | Phosphorylation | Uniprot | |
| K761 | Ubiquitination | Uniprot | |
| T763 | Phosphorylation | Uniprot | |
| S771 | Phosphorylation | Uniprot | |
| T783 | Phosphorylation | Uniprot | |
| T787 | Phosphorylation | Uniprot | |
| K794 | Ubiquitination | Uniprot | |
| Y905 | Phosphorylation | Uniprot | |
| K909 | Ubiquitination | Uniprot | |
| K1055 | Ubiquitination | Uniprot | |
| K1071 | Ubiquitination | Uniprot | |
| S1115 | Phosphorylation | Uniprot | |
| K1132 | Ubiquitination | Uniprot | |
| K1144 | Ubiquitination | Uniprot | |
| S1149 | Phosphorylation | Uniprot | |
| S1153 | Phosphorylation | Uniprot | |
| K1156 | Ubiquitination | Uniprot | |
| Y1158 | Phosphorylation | Uniprot | |
| K1161 | Ubiquitination | Uniprot | |
| S1162 | Phosphorylation | Uniprot | |
| S1165 | Phosphorylation | Uniprot | |
| T1168 | Phosphorylation | Uniprot | |
| T1181 | Phosphorylation | Uniprot | |
| K1194 | Ubiquitination | Uniprot | |
| K1197 | Ubiquitination | Uniprot | |
| Y1212 | Phosphorylation | Uniprot |
研究背景
Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity).
Cell membrane>Multi-pass membrane protein. Cell projection>Cilium>Flagellum membrane>Multi-pass membrane protein.
Isoform XB is the most abundant isoform and is expressed ubiquitously. Isoforms containing segment Z have only been detected in heart, while isoforms containing segment a have been found in heart, stomach and brain cortex.
Interacts with PDZD11. Interacts with SLC35G1 and STIM1. Interacts with calmodulin.
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
研究領域
· Environmental Information Processing > Signal transduction > Calcium signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > cAMP signaling pathway. (View pathway)
· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes. (View pathway)
· Organismal Systems > Endocrine system > Aldosterone synthesis and secretion.
· Organismal Systems > Digestive system > Salivary secretion.
· Organismal Systems > Digestive system > Pancreatic secretion.
参考文献
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