ITPR2 Antibody - #DF13336
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| 製品: | ITPR2 Antibody |
| カタログ: | DF13336 |
| タンパク質の説明: | Rabbit polyclonal antibody to ITPR2 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 308kDa; 308kD(Calculated). |
| ユニプロット: | Q14571 |
| RRID: | AB_2846355 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF13336, RRID:AB_2846355.
折りたたみ／展開
4; 5-trisphosphate receptor; Inositol 1 4 5 trisphosphate receptor type 2; Inositol 1,4,5-trisphosphate receptor type 2; Inositol 145 trisphosphate receptor type 2; InsP3 R2; InsP3R2; IP3 R2; IP3 receptor; IP3 receptor isoform 2; IP3R 2; IP3R2; ITPR 2; Itpr2; ITPR2_HUMAN; Type 2 inositol 1 4 5 trisphosphate receptor; Type 2 inositol 1; Type 2 inositol 145 trisphosphate receptor; Type 2 InsP3 receptor;
免疫原
- Q14571 ITPR2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTEKMSSFLYIGDIVSLYAEGSVNGFISTLGLVDDRCVVHPEAGDLANPPKKFRDCLFKVCPMNRYSAQKQYWKAKQAKQGNHTEAALLKKLQHAAELEQKQNESENKKLLGEIVKYSNVIQLLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSWFYIHPFWKLRSEGDNIVVGDKVVLMPVNAGQPLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVLKGGDVVRLFHAEQEKFLTCDEYEKKQHIFLRTTLRQSATSATSSKALWEIEVVHHDPCRGGAGQWNSLFRFKHLATGNYLAAELNPDYRDAQNEGKNVRDGVPPTSKKKRQAGEKIMYTLVSVPHGNDIASLFELDATTLQRADCLVPRNSYVRLRHLCTNTWVTSTSIPIDTDEERPVMLKIGTCQTKEDKEAFAIVSVPLSEVRDLDFANDANKVLATTVKKLENGTITQNERRFVTKLLEDLIFFVADVPNNGQEVLDVVITKPNRERQKLMREQNILAQVFGILKAPFKEKAGEGSMLRLEDLGDQRYAPYKYMLRLCYRVLRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALLHNNRKLLEKHITAKEIETFVSLLRRNREPRFLDYLSDLCVSNTTAIPVTQELICKFMLSPGNADILIQTKVVSMQADNPMESSILSDDIDDEEVWLYWIDSNKEPHGKAIRHLAQEAKEGTKADLEVLTYYRYQLNLFARMCLDRQYLAINQISTQLSVDLILRCVSDESLPFDLRASFCRLMLHMHVDRDPQESVVPVRYARLWTEIPTKITIHEYDSITDSSRNDMKRKFALTMEFVEEYLKEVVNQPFPFGDKEKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLLAILDIVQAPMSSYFERLSKFQDGGNNVMRTIHGVGEMMTQMVLSRGSIFPMSVPDVPPSIHPSKQGSPTEHEDVTVMDTKLKIIEILQFILSVRLDYRISYMLSIYKKEFGEDNDNAETSASGSPDTLLPSAIVPDIDEIAAQAETMFAGRKEKNPVQLDDEGGRTFLRVLIHLIMHDYPPLLSGALQLLFKHFSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWVEKSSNYENGEIGESQVKGGEEPIEESNILSPVQDGTKKPQIDSNKSNNYRIVKEILIRLSKLCVQNKKCRNQHQRLLKNMGAHSVVLDLLQIPYEKNDEKMNEVMNLAHTFLQNFCRGNPQNQVLLHKHLNLFLTPGLLEAETMRHIFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIVKADGKYVKKCQDMVMTELINGGEDVLIFYNDRASFPILLHMMCSERDRGDESGPLAYHITLVELLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVKIAYVNFVNHCYVDTEVEMKEIYTSNHIWKLFENFLVDMARVCNTTTDRKHADIFLEKCVTESIMNIVSGFFNSPFSDNSTSLQTHQPVFIQLLQSAFRIYNCTWPNPAQKASVESCIRTLAEVAKNRGIAIPVDLDSQVNTLFMKSHSNMVQRAAMGWRLSARSGPRFKEALGGPAWDYRNIIEKLQDVVASLEHQFSPMMQAEFSVLVDVLYSPELLFPEGSDARIRCGAFMSKLINHTKKLMEKEEKLCIKILQTLREMLEKKDSFVEEGNTLRKILLNRYFKGDYSIGVNGHLSGAYSKTAQVGGSFSGQDSDKMGISMSDIQCLLDKEGASELVIDVIVNTKNDRIFSEGIFLGIALLEGGNTQTQYSFYQQLHEQKKSEKFFKVLYDRMKAAQKEIRSTVTVNTIDLGNKKRDDDNELMTSGPRMRVRDSTLHLKEGMKGQLTEASSATSKAYCVYRREMDPEIDIMCTGPEAGNTEEKSAEEVTMSPAIAIMQPILRFLQLLCENHNRELQNFLRNQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVALVNQNLESLTEYCQGPCHENQTCIATHESNGIDIIIALILNDINPLGKYRMDLVLQLKNNASKLLLAIMESRHDSENAERILFNMRPRELVDVMKNAYNQGLECDHGDDEGGDDGVSPKDVGHNIYILAHQLARHNKLLQQMLKPGSDPDEGDEALKYYANHTAQIEIVRHDRTMEQIVFPVPNICEYLTRESKCRVFNTTERDEQGSKVNDFFQQTEDLYNEMKWQKKIRNNPALFWFSRHISLWGSISFNLAVFINLAVALFYPFGDDGDEGTLSPLFSVLLWIAVAICTSMLFFFSKPVGIRPFLVSIMLRSIYTIGLGPTLILLGAANLCNKIVFLVSFVGNRGTFTRGYRAVILDMAFLYHVAYVLVCMLGLFVHEFFYSFLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIIGFLFLKDDFTMEVDRLKNRTPVTGSHQVPTMTLTTMMEACAKENCSPTIPASNTADEEYEDGIERTCDTLLMCIVTVLNQGLRNGGGVGDVLRRPSKDEPLFAARVVYDLLFYFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKSEHNMWHYLYFIVLVKVKDPTEYTGPESYVAQMIVEKNLDWFPRMRAMSLVSNEGDSEQNEIRSLQEKLESTMSLVKQLSGQLAELKEQMTEQRKNKQRLGFLGSNTPHVNHHMPPH
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q14571 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K70 | Ubiquitination | Uniprot | |
| K79 | Ubiquitination | Uniprot | |
| K91 | Ubiquitination | Uniprot | |
| Y117 | Phosphorylation | Uniprot | |
| S118 | Phosphorylation | Uniprot | |
| K130 | Ubiquitination | Uniprot | |
| Y131 | Phosphorylation | Uniprot | |
| T133 | Phosphorylation | Uniprot | |
| K136 | Ubiquitination | Uniprot | |
| K144 | Ubiquitination | Uniprot | |
| S150 | Phosphorylation | Q13557 (CAMK2D) | Uniprot |
| K258 | Ubiquitination | Uniprot | |
| T276 | Phosphorylation | Uniprot | |
| S277 | Phosphorylation | Uniprot | |
| S278 | Phosphorylation | Uniprot | |
| Y386 | Phosphorylation | Uniprot | |
| K450 | Ubiquitination | Uniprot | |
| Y546 | Phosphorylation | Uniprot | |
| Y549 | Phosphorylation | Uniprot | |
| Y551 | Phosphorylation | Uniprot | |
| K569 | Acetylation | Uniprot | |
| K576 | Acetylation | Uniprot | |
| K608 | Acetylation | Uniprot | |
| K608 | Ubiquitination | Uniprot | |
| K613 | Acetylation | Uniprot | |
| K843 | Acetylation | Uniprot | |
| K855 | Ubiquitination | Uniprot | |
| Y903 | Phosphorylation | Uniprot | |
| K909 | Ubiquitination | Uniprot | |
| S937 | Phosphorylation | Uniprot | |
| K1113 | Ubiquitination | Uniprot | |
| K1125 | Ubiquitination | Uniprot | |
| S1160 | Phosphorylation | Uniprot | |
| K1175 | Ubiquitination | Uniprot | |
| K1183 | Ubiquitination | Uniprot | |
| Y1392 | Phosphorylation | Uniprot | |
| K1396 | Ubiquitination | Uniprot | |
| T1443 | Phosphorylation | Uniprot | |
| K1545 | Ubiquitination | Uniprot | |
| S1581 | Phosphorylation | Uniprot | |
| S1584 | Phosphorylation | Uniprot | |
| K1589 | Ubiquitination | Uniprot | |
| K1685 | Acetylation | Uniprot | |
| K1685 | Ubiquitination | Uniprot | |
| Y1708 | Phosphorylation | Uniprot | |
| S1709 | Phosphorylation | Uniprot | |
| T1829 | Phosphorylation | Uniprot | |
| T1845 | Phosphorylation | Uniprot | |
| S1846 | Phosphorylation | Uniprot | |
| S1855 | Phosphorylation | Uniprot | |
| T1856 | Phosphorylation | Uniprot | |
| K1864 | Methylation | Uniprot | |
| T1910 | Phosphorylation | Uniprot | |
| S1912 | Phosphorylation | Uniprot | |
| K2078 | Ubiquitination | Uniprot | |
| K2127 | Ubiquitination | Uniprot | |
| Y2204 | Phosphorylation | Uniprot | |
| K2208 | Ubiquitination | Uniprot | |
| T2380 | Phosphorylation | Uniprot | |
| K2559 | Ubiquitination | Uniprot | |
| S2633 | Phosphorylation | Uniprot | |
| S2636 | Phosphorylation | Uniprot | |
| S2641 | Phosphorylation | Uniprot | |
| K2652 | Ubiquitination | Uniprot | |
| K2671 | Ubiquitination | Uniprot | |
| T2675 | Phosphorylation | Uniprot |
研究背景
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity).
Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.
Endoplasmic reticulum membrane>Multi-pass membrane protein.
Isoform Short is found in skeletal muscle and heart.
Homotetramer (By similarity). Interacts with CABP1. Interacts with BOK; regulates ITPR2 expression (By similarity).
The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
Belongs to the InsP3 receptor family.
研究領域
· Cellular Processes > Cell growth and death > Oocyte meiosis. (View pathway)
· Cellular Processes > Cell growth and death > Apoptosis. (View pathway)
· Cellular Processes > Cell growth and death > Cellular senescence. (View pathway)
· Cellular Processes > Cellular community - eukaryotes > Gap junction. (View pathway)
· Environmental Information Processing > Signal transduction > Calcium signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Phosphatidylinositol signaling system.
· Environmental Information Processing > Signal transduction > Apelin signaling pathway. (View pathway)
· Human Diseases > Neurodegenerative diseases > Alzheimer's disease.
· Human Diseases > Cancers: Overview > Proteoglycans in cancer.
· Organismal Systems > Circulatory system > Vascular smooth muscle contraction. (View pathway)
· Organismal Systems > Immune system > Platelet activation. (View pathway)
· Organismal Systems > Immune system > NOD-like receptor signaling pathway. (View pathway)
· Organismal Systems > Nervous system > Long-term potentiation.
· Organismal Systems > Nervous system > Retrograde endocannabinoid signaling. (View pathway)
· Organismal Systems > Nervous system > Glutamatergic synapse.
· Organismal Systems > Nervous system > Cholinergic synapse.
· Organismal Systems > Nervous system > Serotonergic synapse.
· Organismal Systems > Nervous system > Dopaminergic synapse.
· Organismal Systems > Nervous system > Long-term depression.
· Organismal Systems > Sensory system > Inflammatory mediator regulation of TRP channels. (View pathway)
· Organismal Systems > Endocrine system > Estrogen signaling pathway. (View pathway)
· Organismal Systems > Endocrine system > Thyroid hormone synthesis.
· Organismal Systems > Endocrine system > Oxytocin signaling pathway.
· Organismal Systems > Endocrine system > Glucagon signaling pathway.
· Organismal Systems > Endocrine system > Renin secretion.
· Organismal Systems > Endocrine system > Aldosterone synthesis and secretion.
· Organismal Systems > Digestive system > Salivary secretion.
· Organismal Systems > Digestive system > Gastric acid secretion.
· Organismal Systems > Digestive system > Pancreatic secretion.
参考文献
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