TRPC3 Antibody - #DF13397
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF13397, RRID:AB_2846416.
折りたたみ／展開
Htrp 3; Htrp3; MGC124333; Mtrp3; Receptor activated cation channel TRP3; Short transient receptor potential channel 3; Transient receptor potential cation channel subfamily C member 3; transient receptor potential cation channel subfamily C member 3 variant c; Transient receptor potential channel 3; TRANSIENT RECEPTOR POTENTIAL DROSOPHILA HOMOLOG OF 3; Transient receptor protein 3; Trp related protein 3; TRP3; TrpC3; Trrp3;
免疫原
Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis.
- Q13507 TRPC3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRRRLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKLNPSMLRCE
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q13507 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y37 | Phosphorylation | Uniprot | |
| Y136 | Phosphorylation | Uniprot | |
| Y138 | Phosphorylation | Uniprot | |
| S199 | Phosphorylation | Uniprot | |
| S201 | Phosphorylation | Uniprot | |
| Y214 | Phosphorylation | Uniprot | |
| S251 | Phosphorylation | Q13976 (PRKG1) | Uniprot |
| S295 | Phosphorylation | Uniprot | |
| N404 | N-Glycosylation | Uniprot | |
| Y543 | Phosphorylation | Uniprot | |
| T561 | Phosphorylation | Uniprot | |
| S669 | Phosphorylation | Uniprot | |
| S696 | Phosphorylation | Uniprot | |
| S700 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| S703 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| Y706 | Phosphorylation | Uniprot | |
| S752 | Phosphorylation | Uniprot | |
| S800 | Phosphorylation | Uniprot | |
| Y804 | Phosphorylation | Uniprot | |
| S831 | Phosphorylation | Uniprot |
研究背景
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.
Membrane>Multi-pass membrane protein.
Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis.
Interacts with TRPC1, ITPR1, ITPR3, MX1 and RNF24. Interacts with JPH2; the interaction is involved in maintaining Ca(2+) homeostasis in skeletal muscle and is mediated by JPH2 'Ser-165' phosphorylation.
Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC3 sub-subfamily.
研究領域
· Organismal Systems > Development > Axon guidance. (View pathway)
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