AKR1B10 Antibody - #DF13405
| 製品: | AKR1B10 Antibody |
| カタログ: | DF13405 |
| タンパク質の説明: | Rabbit polyclonal antibody to AKR1B10 |
| アプリケーション: | WB IHC |
| 反応性: | Human |
| 分子量: | 36kDa; 36kD(Calculated). |
| ユニプロット: | O60218 |
| RRID: | AB_2846424 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF13405, RRID:AB_2846424.
折りたたみ／展開
AK1BA_HUMAN; AKR1B10; AKR1B11; AKR1B12; Aldo keto reductase family 1 member B10; aldo keto reductase family 1 member B11; Aldo-keto reductase family 1 member B10 (aldose reductase); Aldo-keto reductase family 1 member B10; Aldo-keto reductase family 1 member B11 (aldose reductase-like); aldose reductase like 1; Aldose reductase like; aldose reductase like peptide; Aldose reductase related protein; Aldose reductase-like; Aldose reductase-related protein; ALDRLn; ARL 1; ARL-1; ARL1; ARL1 Human small intestine reductase; ARP; hARP; HIS; HSI; SI reductase; Small intestine reductase;
免疫原
Found in many tissues. Highly expressed in small intestine, colon and adrenal gland.
- O60218 AK1BA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACNVLQSSHLEDYPFNAEY
PTMs - O60218 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S23 | Phosphorylation | Uniprot | |
| K27 | Acetylation | Uniprot | |
| Y40 | Phosphorylation | Uniprot | |
| Y47 | Phosphorylation | Uniprot | |
| Y49 | Phosphorylation | Uniprot | |
| K69 | Acetylation | Uniprot | |
| R70 | Methylation | Uniprot | |
| K95 | Acetylation | Uniprot | |
| K125 | Acetylation | Uniprot | |
| T137 | Phosphorylation | Uniprot | |
| K173 | Ubiquitination | Uniprot | |
| K177 | Ubiquitination | Uniprot | |
| K179 | Acetylation | Uniprot | |
| Y190 | Phosphorylation | Uniprot | |
| Y199 | Phosphorylation | Uniprot | |
| S215 | Phosphorylation | Uniprot | |
| K263 | Acetylation | Uniprot | |
| S282 | Phosphorylation | Uniprot | |
| T288 | Phosphorylation | Uniprot | |
| S291 | Phosphorylation | Uniprot | |
| Y310 | Phosphorylation | Uniprot | |
| Y316 | Phosphorylation | Uniprot |
研究背景
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays strong enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls). Displays no reductase activity towards glucose.
Lysosome. Secreted.
Note: Secreted through a lysosome-mediated non-classical pathway.
Found in many tissues. Highly expressed in small intestine, colon and adrenal gland.
Belongs to the aldo/keto reductase family.
研究領域
· Metabolism > Carbohydrate metabolism > Pentose and glucuronate interconversions.
· Metabolism > Carbohydrate metabolism > Fructose and mannose metabolism.
· Metabolism > Carbohydrate metabolism > Galactose metabolism.
· Metabolism > Lipid metabolism > Glycerolipid metabolism.
· Metabolism > Metabolism of cofactors and vitamins > Folate biosynthesis.
· Metabolism > Global and overview maps > Metabolic pathways.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.