KCNK5 Antibody - #DF13412
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF13412, RRID:AB_2846431.
折りたたみ／展開
Acid sensitive potassium channel protein TASK 2; Acid-sensitive potassium channel protein TASK-2; FLJ11035; K2p5.1; KCNK 5; KCNK5; KCNK5_HUMAN; Potassium channel subfamily K member 1; Potassium channel subfamily K member 5; TASK 2; TASK2; TWIK related acid sensitive K(+) channel 2; TWIK related acid sensitive K+ channel 2; TWIK-related acid-sensitive K(+) channel 2;
免疫原
Abundant expression in kidney, also detected in liver, placenta and small intestine. In the kidney, expression is restricted to the distal tubules and collecting ducts. Not expressed in proximal tubules or glomeruli.
- O95279 KCNK5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVDRGPLLTSAIIFYLAIGAAIFEVLEEPHWKEAKKNYYTQKLHLLKEFPCLGQEGLDKILEVVSDAAGQGVAITGNQTFNNWNWPNAMIFAATVITTIGYGNVAPKTPAGRLFCVFYGLFGVPLCLTWISALGKFFGGRAKRLGQFLTKRGVSLRKAQITCTVIFIVWGVLVHLVIPPFVFMVTEGWNYIEGLYYSFITISTIGFGDFVAGVNPSANYHALYRYFVELWIYLGLAWLSLFVNWKVSMFVEVHKAIKKRRRRRKESFESSPHSRKALQVKGSTASKDVNIFSFLSKKEETYNDLIKQIGKKAMKTSGGGETGPGPGLGPQGGGLPALPPSLVPLVVYSKNRVPTLEEVSQTLRSKGHVSRSPDEEAVARAPEDSSPAPEVFMNQLDRISEECEPWDAQDYHPLIFQDASITFVNTEAGLSDEETSKSSLEDNLAGEESPQQGAEAKAPLNMGEFPSSSESTFTSTESELSVPYEQLMNEYNKANSPKGT
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O95279 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K36 | Ubiquitination | Uniprot | |
| K42 | Ubiquitination | Uniprot | |
| K47 | Ubiquitination | Uniprot | |
| S131 | Phosphorylation | Uniprot | |
| K150 | Ubiquitination | Uniprot | |
| S266 | Phosphorylation | Uniprot | |
| K275 | Ubiquitination | Uniprot | |
| K280 | Ubiquitination | Uniprot | |
| S282 | Phosphorylation | Uniprot | |
| T283 | Phosphorylation | Uniprot | |
| S285 | Phosphorylation | Uniprot | |
| K286 | Ubiquitination | Uniprot | |
| K296 | Ubiquitination | Uniprot | |
| K297 | Ubiquitination | Uniprot | |
| T300 | Phosphorylation | Uniprot | |
| Y301 | Phosphorylation | Uniprot | |
| K306 | Ubiquitination | Uniprot | |
| Y347 | Phosphorylation | Uniprot | |
| T354 | Phosphorylation | Uniprot | |
| S371 | Phosphorylation | Uniprot | |
| Y410 | Phosphorylation | Uniprot | |
| S437 | Phosphorylation | Uniprot | |
| S438 | Phosphorylation | Uniprot |
研究背景
pH-dependent, voltage insensitive, outwardly rectifying potassium channel. Outward rectification is lost at high external K(+) concentrations.
Membrane>Multi-pass membrane protein.
Abundant expression in kidney, also detected in liver, placenta and small intestine. In the kidney, expression is restricted to the distal tubules and collecting ducts. Not expressed in proximal tubules or glomeruli.
Homodimer; disulfide-linked.
Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
研究領域
· Organismal Systems > Sensory system > Taste transduction.
· Organismal Systems > Digestive system > Protein digestion and absorption.
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