alpha 1 Spectrin Antibody - #DF13417
(4)
| 製品: | alpha 1 Spectrin Antibody |
| カタログ: | DF13417 |
| タンパク質の説明: | Rabbit polyclonal antibody to alpha 1 Spectrin |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Horse |
| 分子量: | 280kDa, 110 kDa; 280kD(Calculated). |
| ユニプロット: | P02549 |
| RRID: | AB_2846436 |
製品説明
ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
反応性:
Human,Mouse,Rat
予測:
Horse(100%)
クローナリティ:
Polyclonal
特異性:
alpha 1 Spectrin Antibody detects endogenous levels of total alpha 1 Spectrin.
RRID:
AB_2846436
引用形式: Affinity Biosciences Cat# DF13417, RRID:AB_2846436.
引用形式: Affinity Biosciences Cat# DF13417, RRID:AB_2846436.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:
折りたたみ／展開
Alpha I spectrin; EL 2; EL2; Elliptocytosis 2; Elliptocytosis2; Erythrocyte alpha spectrin; erythrocyte; Erythroid alpha spectrin; Erythroid alpha-spectrin; Erythroid spectrin alpha; HPP; HS3; Spectrin alpha chain; Spectrin alpha chain erythrocyte; Spectrin alpha erythrocytic 1; SPH3; SPTA 1; SPTA; SPTA1; SPTA1_HUMAN;
免疫原
免疫原:
Uniprot:
遺伝子(ID):
タンパク質配列:
- P02549 SPTA1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEQFPKETVVESSGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNLEDALILDIKYSTIGLAQQWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETLKEFSTIYKHFDENLTGRLTHKEFRSCLRGLNYYLPMVEEDEHEPKFEKFLDAVDPGRKGYVSLEDYTAFLIDKESENIKSSDEIENAFQALAEGKSYITKEDMKQALTPEQVSFCATHMQQYMDPRGRSHLSGYDYVGFTNSYFGN
種類予測
種類予測:
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
Species
Results
Score
Horse
100
Pig
0
Bovine
0
Sheep
0
Dog
0
Xenopus
0
Zebrafish
0
Chicken
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P02549 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S37 | Phosphorylation | Uniprot | |
| K59 | Acetylation | Uniprot | |
| S96 | Phosphorylation | Uniprot | |
| S261 | Phosphorylation | Uniprot | |
| K283 | Acetylation | Uniprot | |
| S299 | Phosphorylation | Uniprot | |
| S317 | Phosphorylation | Uniprot | |
| Y370 | Phosphorylation | Uniprot | |
| Y422 | Phosphorylation | Uniprot | |
| S507 | Phosphorylation | Uniprot | |
| S510 | Phosphorylation | Uniprot | |
| Y548 | Phosphorylation | Uniprot | |
| Y588 | Phosphorylation | Uniprot | |
| T635 | Phosphorylation | Uniprot | |
| T812 | Phosphorylation | Uniprot | |
| S818 | Phosphorylation | Uniprot | |
| S844 | O-Glycosylation | Uniprot | |
| Y986 | Phosphorylation | Uniprot | |
| S992 | Phosphorylation | Uniprot | |
| Y1064 | Phosphorylation | Uniprot | |
| S1167 | Phosphorylation | Uniprot | |
| S1250 | O-Glycosylation | Uniprot | |
| T1257 | Phosphorylation | Uniprot | |
| S1284 | Phosphorylation | Uniprot | |
| S1363 | Phosphorylation | Uniprot | |
| S1424 | Phosphorylation | Uniprot | |
| S1425 | Phosphorylation | Uniprot | |
| S1428 | Phosphorylation | Uniprot | |
| K1486 | Ubiquitination | Uniprot | |
| Y1499 | Phosphorylation | Uniprot | |
| Y1538 | Phosphorylation | Uniprot | |
| K1579 | Acetylation | Uniprot | |
| K1586 | Acetylation | Uniprot | |
| S1738 | O-Glycosylation | Uniprot | |
| K1803 | Ubiquitination | Uniprot | |
| S1901 | Phosphorylation | Uniprot | |
| T1910 | Phosphorylation | Uniprot | |
| S1912 | Phosphorylation | Uniprot | |
| S1976 | Phosphorylation | Uniprot | |
| K2051 | Acetylation | Uniprot | |
| K2200 | Acetylation | Uniprot | |
| S2269 | Phosphorylation | Uniprot | |
| T2288 | Phosphorylation | Uniprot | |
| Y2333 | Phosphorylation | Uniprot | |
| S2335 | Phosphorylation | Uniprot | |
| S2405 | Phosphorylation | Uniprot | |
| Y2407 | Phosphorylation | Uniprot |
研究背景
機能:
Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.
細胞の位置付け:
Cytoplasm>Cytoskeleton. Cytoplasm>Cell cortex.
サブユニット構造:
Composed of non-homologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. Interacts with FASLG.
タンパク質ファミリー:
Belongs to the spectrin family.
研究領域
· Cellular Processes > Cell growth and death > Apoptosis. (View pathway)
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