DR3 Antibody - #DF13469
| 製品: | DR3 Antibody |
| カタログ: | DF13469 |
| タンパク質の説明: | Rabbit polyclonal antibody to DR3 |
| アプリケーション: | WB |
| 反応性: | Human |
| 予測: | Bovine, Sheep |
| 分子量: | 45kDa; 45kD(Calculated). |
| ユニプロット: | Q93038 |
| RRID: | AB_2846488 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF13469, RRID:AB_2846488.
折りたたみ／展開
Apo 3; Apo-3; Apo3; Apoptosis inducing receptor AIR; Apoptosis inducing receptor; Apoptosis mediating receptor; Apoptosis mediating receptor DR 3; Apoptosis mediating receptor DR3; Apoptosis mediating receptor TRAMP; Apoptosis-inducing receptor AIR; Apoptosis-mediating receptor DR3; Apoptosis-mediating receptor TRAMP; DDR 3; DDR3; Death domain receptor 3; Death domain receptor 3 soluble form; Death receptor 3; Death receptor beta; DR 3; DR3; LARD; Lymphocyte associated receptor of death; Lymphocyte-associated receptor of death; Protein WSL; Protein WSL-1; TNF receptor superfamily member 25; TNFR25; TNFRSF 12; TNFRSF 25; TNFRSF12; TNFRSF12, formerly; TNFRSF25; TNR25_HUMAN; TR 3; TR3; TRAMP; Translocating chain association membrane protein; Tumor necrosis factor receptor superfamily member 12; Tumor necrosis factor receptor superfamily member 25; Tumor necrosis factor receptor superfamily, member 12 (translocating chain association membrane protein); Tumor necrosis factor receptor superfamily, member 12, formerly; WSL 1; WSL; WSL LR; WSL protein; WSL1; WSL1 protein; WSLLR;
免疫原
Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate.
- Q93038 TNR25_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEQRPRGCAAVAAALLLVLLGARAQGGTRSPRCDCAGDFHKKIGLFCCRGCPAGHYLKAPCTEPCGNSTCLVCPQDTFLAWENHHNSECARCQACDEQASQVALENCSAVADTRCGCKPGWFVECQVSQCVSSSPFYCQPCLDCGALHRHTRLLCSRRDTDCGTCLPGFYEHGDGCVSCPTSTLGSCPERCAAVCGWRQMFWVQVLLAGLVVPLLLGATLTYTYRHCWPHKPLVTADEAGMEALTPPPATHLSPLDSAHTLLAPPDSSEKICTVQLVGNSWTPGYPETQEALCPQVTWSWDQLPSRALGPAAAPTLSPESPAGSPAMMLQPGPQLYDVMDAVPARRWKEFVRTLGLREAEIEAVEVEIGRFRDQQYEMLKRWRQQQPAGLGAVYAALERMGLDGCVEDLRSRLQRGP
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q93038 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y376 | Phosphorylation | Uniprot | |
| Y394 | Phosphorylation | Uniprot |
研究背景
Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.
Glycosylated.
Cell membrane>Single-pass type I membrane protein.
Cell membrane>Single-pass type I membrane protein.
Cell membrane>Single-pass type I membrane protein.
Cell membrane>Single-pass type I membrane protein.
Secreted.
Secreted.
Secreted.
Secreted.
Secreted.
Secreted.
Secreted.
Secreted.
Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate.
Homodimer. Interacts strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4.
研究領域
· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction. (View pathway)
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.