製品: GCP2 Antibody
カタログ: DF13470
タンパク質の説明: Rabbit polyclonal antibody to GCP2
アプリケーション: WB IHC IF/ICC
反応性: Human, Mouse, Rat
予測: Bovine
分子量: 11kDa; 12kD(Calculated).
ユニプロット: P80162
RRID: AB_2846489

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 200ul $350 在庫あり

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製品説明

ソース:
Rabbit
アプリケーション:
IF/ICC 1:100-1:500, WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Bovine(100%)
クローナリティ:
Polyclonal
特異性:
GCP2 Antibody detects endogenous levels of total GCP2.
RRID:
AB_2846489
引用形式: Affinity Biosciences Cat# DF13470, RRID:AB_2846489.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

C X C motif chemokine 6; Chemokine (C X C motif) ligand 6; Chemokine alpha 3; CKA 3; CKA-3; CKA3; CXCL 6; CXCL6; CXCL6_HUMAN; GCP 2; GCP-2; Granulocyte chemotactic protein 2; N-processed variant 3; SCYB6; Small inducible cytokine B6; Small inducible cytokine subfamily B (Cys X Cys) member 6; Small inducible cytokine subfamily B (Cys X Cys) member b; Small-inducible cytokine B6;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
タンパク質配列:
MSLPSSRAARVPGPSGSLCALLALLLLLTPPGPLASAGPVSAVLTELRCTCLRVTLRVNPKTIGKLQVFPAGPQCSKVEVVASLKNGKQVCLDPEAPFLKKVIQKILDSGNKKN

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Bovine
100
Pig
0
Horse
0
Sheep
0
Dog
0
Xenopus
0
Zebrafish
0
Chicken
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P80162 基板として

Site PTM Type Enzyme
T62 Phosphorylation

研究背景

機能:

Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7).

細胞の位置付け:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
タンパク質ファミリー:

Belongs to the intercrine alpha (chemokine CxC) family.

研究領域

· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction.   (View pathway)

· Human Diseases > Infectious diseases: Bacterial > Pertussis.

· Human Diseases > Immune diseases > Rheumatoid arthritis.

· Organismal Systems > Immune system > Chemokine signaling pathway.   (View pathway)

· Organismal Systems > Immune system > IL-17 signaling pathway.   (View pathway)

参考文献

1). Ethanol promoting the upregulation of C-X-C Motif Chemokine Ligand 1(CXCL1) and C-X-C Motif Chemokine Ligand 6(CXCL6) in models of early alcoholic liver disease. Bioengineered, 2022 (PubMed: 35156518) [IF=4.9]

Application: IHC    Species: Mice    Sample: liver tissues

Figure 8. The proteins levels of CXCL1 and CXCL6 in (a) mice and (b) hepatocellular models of early ALD. CXCL1:C-X-C Motif Chemokine Ligand 1; CXCL6:C-X-C Motif Chemokine Ligand 6; ALD: alcoholic liver disease.

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Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.