KCNK10 Antibody - #DF13480
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF13480, RRID:AB_2846499.
折りたたみ／展開
2P domain potassium channel TREK2; K2p10.1; KCNK10; KCNKA_HUMAN; Outward rectifying potassium channel protein TREK 2; Outward rectifying potassium channel protein TREK-2; Potassium channel subfamily K member 10; Potassium channel TREK 2; TREK 2; TREK 2 K; TREK 2 K(+) channel subunit; TREK-2 K(+) channel subunit; TREK2; TWIK related K+ channel 2;
免疫原
Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine. Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas isoform c is abundantly expressed in brain.
- P57789 KCNKA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MFFLYTDFFLSLVAVPAAAPVCQPKSATNGQPPAPAPTPTPRLSISSRATVVARMEGTSQGGLQTVMKWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHVCVSPQELETLIQHALDADNAGVSPIGNSSNNSSHWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEKVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVGEIKAHAAEWKANVTAEFRETRRRLSVEIHDKLQRAATIRSMERRRLGLDQRAHSLDMLSPEKRSVFAALDTGRFKASSQESINNRPNNLRLKGPEQLNKHGQGASEDNIINKFGSTSRLTKRKNKDLKKTLPEDVQKIYKTFRNYSLDEEKKEEETEKMCNSDNSSTAMLTDCIQQHAELENGMIPTDTKDREPENNSLLEDRN
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P57789 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y82 | Phosphorylation | Uniprot | |
| T85 | Phosphorylation | Uniprot | |
| S359 | Phosphorylation | Uniprot | |
| K365 | Ubiquitination | Uniprot | |
| Y479 | Phosphorylation | Uniprot |
研究背景
Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.
Membrane>Multi-pass membrane protein.
Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine. Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas isoform c is abundantly expressed in brain.
Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
研究領域
· Organismal Systems > Digestive system > Gastric acid secretion.
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