IEX1 Antibody - #DF13488
| 製品: | IEX1 Antibody |
| カタログ: | DF13488 |
| タンパク質の説明: | Rabbit polyclonal antibody to IEX1 |
| アプリケーション: | WB IHC |
| 反応性: | Human |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit |
| 分子量: | 16kDa; 17kD(Calculated). |
| ユニプロット: | P46695 |
| RRID: | AB_2846507 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF13488, RRID:AB_2846507.
折りたたみ／展開
DIF2; Differentiation-dependent gene 2 protein; GLY96; IER3; IEX1_HUMAN; IEX1L; Immediate early protein GLY96; Immediate early response 3; Immediate early response 3 protein; Immediately early gene X 1; PACAP-responsive gene 1 protein; PRG 1; PRG1; Protein DIF 2; Protein DIF-2; Protein PRG1; Radiation-inducible immediate-early gene IEX-1;
免疫原
- P46695 IEX1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MCHSRSCHPTMTILQAPTPAPSTIPGPRRGSGPEIFTFDPLPEPAAAPAGRPSASRGHRKRSRRVLYPRVVRRQLPVEEPNPAKRLLFLLLTIVFCQILMAEEGVPAPLPPEDAPNAASLAPTPVSAVLEPFNLTSEPSDYALDLSTFLQQHPAAF
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P46695 基板として
研究背景
May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment.
Phosphorylated at Thr-18, Thr-123 and Ser-126 by MAPK1/ERK2 and probably MAPK3/ERK1. Upon phosphorylation by MAPK1/ERK2 and MAPK3/ERK1, acquires the ability to inhibit cell death induced by various stimuli.
Glycosylated.
Membrane>Single-pass type II membrane protein.
Interacts with the PPP2R5C-PP2A holoenzyme and ERK kinases; regulates ERK dephosphorylation.
Belongs to the IER3 family.
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